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| http://dx.doi.org/10.1016/j.yhbeh.2018.05.001 | DOI Listing |
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Fantastic proteins and where to find them - histones, in the nucleus and beyond.
J Cell Sci
December 2024
Epigenetics, Babraham Institute, Cambridge CB22 3AT, UK.
Animal genomes are packaged into chromatin, a highly dynamic macromolecular structure of DNA and histone proteins organised into nucleosomes. This accommodates packaging of lengthy genomic sequences within the physical confines of the nucleus while also enabling precise regulation of access to genetic information. However, histones existed before chromatin and have lesser-known functions beyond genome regulation.
View Article and Find Full Text PDF[Knockout of in HEK293 cells by CRISPR/Cas9].
Sheng Wu Gong Cheng Xue Bao
November 2024
College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, Zhejiang, China.
We knocked out the retinoic acid-inducible gene I (- in HEK293 cells CRISPR/Cas9 to reveal the effects of knockout on the key factors in the type I interferon signaling pathway. Three single guide RNAs (sgRNAs) targeting were designed, and the recombination vectors were constructed on the basis of the pX459 vector and used to transfect HEK293 cells, which were screened by puromycin subsequently. Furthermore, a mimic of virus, poly I: C, was used to transfect the cells screened out.
View Article and Find Full Text PDFThyroid Hormone Action by Genomic and Nongenomic Molecular Mechanisms.
Methods Mol Biol
November 2024
Instituto de Investigaciones Biomédicas "Sols-Morreale", Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain.
The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are pivotal in regulating various physiological processes including growth, development, and metabolism. The biological actions of thyroid hormones are primarily initiated by binding to nuclear thyroid hormone receptors (TRs). These receptors, belonging to the superfamily of nuclear receptors, act as ligand-dependent transcription factors.
View Article and Find Full Text PDFGenome-wide identification of the eggplant jasmonate ZIM-domain (JAZ) gene family and functional characterization of SmJAZ10 in modulating chlorophyll synthesis in leaves.
Int J Biol Macromol
December 2024
School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:
Article Synopsis
- The jasmonate ZIM-domain (JAZ) gene family is important in regulating key traits in crops, but its characterization in eggplants was previously unreported.
- In this study, researchers identified 13 SmJAZ genes on 9 chromosomes, classified into 5 subgroups, and found their involvement in various plant responses to environmental stimuli.
- Additionally, overexpressing SmJAZ10 reduced chlorophyll content in seedlings and altered the expression of related genes, suggesting its potential role in enhancing eggplant quality through jasmonate signaling.
High prevalence of chromosome 17 in breast cancer micronuclei: a means to get rid of tumor suppressors?
Hum Cell
October 2024
Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Micronuclei (MN), defined as small extra-nuclear chromatin bodies enclosed by a nuclear envelope, serve as noticeable markers of chromosomal instability (CIN). The MN have been used for breast cancer (BC) screening, diagnosis, and prognosis. However, more recently they have gained attention as seats for active chromosomal rearrangements.
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