Apelin, a regulatory peptide, is a ligand of the APJ receptor that belongs to the G protein-coupled receptor family. Apelin and APJ are widely distributed in the body and play potential physiological roles in the cytoprotection of many internal organs. This review article summarizes information about the roles of the apelin/APJ system in neurological, metabolic, hypertension, respiratory, gastrointestinal, hepatic, kidney and cancerous diseases. It is suggested that apelin positively affects the treatment of non-cancerous diseases and may be considered as a therapeutic drug in many illnesses. However, in cancers, apelin appears as a tumour growth stimulator, and its suggested role is as a marker in the diagnosis of tumour cancers in tissues. In summary, apelin has certain therapeutic abilities and can be useful in the treatment of, e.g., insulin resistance, hypertension, etc., but it also can sometimes serve as a negative factor.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cca.2018.05.012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Novel Insight into the Role of Obesity-Related Adipokines in Ovarian Cancer-State-of-the-Art Review and Future Perspectives.
Int J Mol Sci
February 2025
Department of Clinical Molecular Biology, Medical University of Białystok, 15-269 Białystok, Poland.
Ovarian cancer (OC) is one of the most fatal gynecological neoplasms. Meta-analyses have shown that the relationship between body mass index (BMI) and ovarian cancer incidence was detected in some types of ovarian cancer. Chronic inflammation and excessive accumulation of free fatty acids are key adipose tissue-derived factors initiating cancer development.
View Article and Find Full Text PDFCan apelins guide the diagnosis of coronary artery disease in COPD patients?
Heart Lung
March 2025
Depertment of Pulmonary Diseases, Ataturk University School of Medicine, Yakutiye, Erzurum, Turkey.
Background: Apelins are adipokines known for their anti-inflammatory, vasodilator, and antiatherosclerotic effects. They are involved in the pathogenesis of chronic diseases like chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD).
Objectives: This study aims to investigate apelin as a potential biomarker for early diagnosis and management of CAD in COPD patients.
Apelin-13 Alleviates Diabetes-Associated Cognitive Decline by Reducing Oxidative Stress and Mitochondrial Dysfunction via the SIRT3/Foxo3 Pathway.
Biotechnol Appl Biochem
March 2025
Department of Emergency, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
The incidence of diabetes-related cognitive dysfunction is on the rise, yet clinical interventions to prevent this condition remain limited. Apelin-13, an endogenous peptide known for its positive inotropic and vasoactive properties, has been shown to exert diverse effects across various tissues and cell types. However, its potential protective role in diabetes-associated cognitive decline (DACD) remains poorly understood.
View Article and Find Full Text PDFApelin/APJ alleviates diabetic nephropathy by improving glomerular endothelial cells dysfunction via SIRT3‑KLF15.
Mol Med Rep
May 2025
Department of Physiology and Pathophysiology, Capital Medical University, Beijing 100069, P.R. China.
Glomerular basement membrane (GBM) thickening, the earliest morphological change of diabetic nephropathy (DN), is related to glomerular endothelial cells (GECs) dysfunction which increase extracellular matrix (ECM) synthesizing. Apelin, the endogenous ligand for apelin/apelin receptor (APJ), is reported to alleviate endothelial cell dysfunction in DN. Therefore, it was hypothesized that apelin/APJ reduced GBM thickening by decreasing the synthesis of ECM in GECs.
View Article and Find Full Text PDFInsufficient expression of COL6A1 promotes the development of early-onset severe preeclampsia by inhibiting the APJ/AKT signaling pathway.
Cell Death Discov
March 2025
Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, China.
Early-onset severe preeclampsia (eosPE) is one of the most severe complications of pregnancy. To identify the genes related to the development of eosPE. We downloaded and integrated analyzed microarray data from GSE44711, GSE66273, and GSE74341, which contains the expression profile of placental tissues from patients with eosPE and healthy controls.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!