AI Article Synopsis
- Liposarcoma is a rare tumor found in rats, characterized by lipoblasts with multiple vacuoles.
- A long-term study on a male SD rat revealed a rare type of liposarcoma with extensive fatty tissue, kidney nodules, and liver paleness upon necropsy at 105 weeks.
- The tumor showed both well-differentiated and high-grade dedifferentiated components, and metastasis was confirmed in various organs, marking the first report of this highly metastatic liposarcoma in rats.
Article Abstract
Liposarcoma is a rare neoplasm in rats and is characterized by the presence of lipoblasts containing multiple cytoplasmic vacuoles. We encountered a rare type of liposarcoma in a male SD (Crj:CD(SD)IGS) rat during a long-term study to gather background data. At necropsy at 105 weeks of age, there was a large amount of fatty tissue covering the mesentery, pancreas, and retroperitoneum; a white nodule in the right kidney; and paleness of the liver. Microscopically, the tumor had a well-differentiated component and dedifferentiated high-grade component. Immunohistochemical and electron microscopic examinations revealed that the pleomorphic tumor cells retained the characteristics of lipoblasts. Distant or disseminated metastasis was also confirmed in various organs. A liposarcoma with these histological features is extremely rare in rats, and this is the first report of a highly metastatic dedifferentiated type of liposarcoma originating from the abdominal fat tissue in a rat.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938215 | PMC |
| http://dx.doi.org/10.1293/tox.2017-0055 | DOI Listing |
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