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Influence of sleep on physiological systems in atherosclerosis.
Nat Cardiovasc Res
November 2024
Cardiovascular Research Institute and the Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Article Synopsis
- * Research from animal studies to large human populations reveals that insufficient or inconsistent sleep harms cardiovascular wellness by disturbing vital body systems.
- * Ongoing studies are uncovering the connections between sleep and factors like the autonomic nervous, metabolic, and immune systems that contribute to cardiovascular diseases such as atherosclerosis.
Myocardial infarction augments sleep to limit cardiac inflammation and damage.
Nature
November 2024
Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Article Synopsis
- Sleep plays a crucial role in heart health, especially after a heart attack (myocardial infarction), by influencing inflammatory responses and healing processes.
- After a heart attack, certain immune cells (monocytes) are recruited to the brain to promote sleep, which helps reduce harmful stress on the heart and supports recovery.
- Disruption of sleep can worsen heart function and increase the risk of further cardiovascular issues, as poor sleep can reprogram immune cells in a way that enhances inflammation and hinders the healing process.
Lower your cholesterol early, and stick with it!
Nat Rev Cardiol
October 2024
Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Hematopoietic aging promotes cancer by fueling IL-1⍺-driven emergency myelopoiesis.
Science
October 2024
Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Article Synopsis
- Aging increases the risk of cancer by affecting how the immune system works, especially in lung tumors.
- Older immune cells lead to the buildup of certain cells that produce IL-1⍺, which makes cancer grow faster.
- By blocking IL-1R1 signaling early on, scientists found they could slow down cancer growth in the lungs, colon, and pancreas, and learned how aging is linked to worse cancer outcomes in humans.
A γδ T cell-IL-3 axis controls allergic responses through sensory neurons.
Nature
October 2024
Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
In naive individuals, sensory neurons directly detect and respond to allergens, leading to both the sensation of itch and the activation of local innate immune cells, which initiate the allergic immune response. In the setting of chronic allergic inflammation, immune factors prime sensory neurons, causing pathologic itch. Although these bidirectional neuroimmune circuits drive responses to allergens, whether immune cells regulate the set-point for neuronal activation by allergens in the naive state is unknown.
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