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Article Synopsis
- Sarcoidosis is a multisystem disease that commonly affects African American women and people of Scandinavian descent, characterized by noncaseating granulomas.
- A 29-year-old African American male presented with recurrent symptoms related to gallstones, specifically right upper quadrant pain after eating, and was found to have cholelithiasis on imaging.
- During an elective surgery for gallbladder removal, liver lesions were discovered, and a biopsy revealed noncaseating granulomas consistent with sarcoidosis, indicating an unusual manifestation of the disease in the liver and lymph nodes.
Background: Laparoscopic sleeve gastrectomy (LSG) specimens are histologically analyzed to identify incidental pathologies. However, no guidelines recommend routine histology. This study evaluates the clinical utility of LSG sample analysis and if incidental diagnoses have a significant clinical impact.
View Article and Find Full Text PDFThe First Case of Schaumann Bodies in Pediatric Very Early Onset Crohn's Disease: Case Report and Literature Review.
Children (Basel)
October 2024
Institute of Pathology 'Prof. Dr. Đorđe Joannović', Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Article Synopsis
- - Crohn's disease (CD) is a rising chronic inflammatory bowel condition that's tough to diagnose due to unclear criteria, often needing teamwork between doctors and pathologists.
- - The disease typically shows transmural inflammation and can include rare features like Schaumann bodies (SB), which are seldom found in CD cases (around 10%).
- - A case of a 4-year-old girl with severe symptoms led to the discovery of SB in her gastric mucosa, helping to confirm her diagnosis of early-onset CD and demonstrating the need to differentiate it from similar diseases.
Gastrointestinal Manifestations of Sarcoidosis: A State-of-the-Art, Comprehensive Review of the Literature-Practical Clinical Insights and Many Unmet Needs on Diagnosis and Treatment.
Pharmaceuticals (Basel)
August 2024
Pulmonology Unit, Department of Medical Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy.
Article Synopsis
- This literature review examines the role of the gastrointestinal (GI) tract in sarcoidosis, which is a rare inflammatory disease that can be difficult to diagnose and treat due to overlapping symptoms with other GI disorders.* -
- GI sarcoidosis can impact any area of the gastrointestinal system, particularly the stomach and small intestine, leading to symptoms that range from mild discomfort to serious complications like obstruction or perforation.* -
- Current treatment options primarily involve corticosteroids, but their long-term effectiveness and safety are questionable, highlighting the urgent need for better diagnostic methods and standardized treatment protocols.*
Hypercalcaemia in gastrointestinal stromal tumour and sarcoidosis: a case report.
BMC Nephrol
July 2024
Department of Renal Medicine, Nepean Hospital, Sydney, NSW, Australia.
Background: Hypercalcaemia is a common manifestation of sarcoidosis but is sparingly described in gastrointestinal stromal tumours (GISTs). We describe a case of acute kidney injury and hypercalcemia resulting from simultaneous diagnosis of GIST and sarcoidosis, the presentation of which has not yet been reported.
Case Presentation: A 61-year-old male presented with acute kidney injury and hypercalcemia, with elevated 1,25-dihydroxyvitamin D levels.
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