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A 73-year-old man presented with nausea, abdominal discomfort, and distention persisting for the past five days. He had previously been diagnosed with stage III peripheral CD4+ T cell lymphoma and had initiated chemotherapy comprising vincristine two weeks prior to presentation. An evaluation revealed diffuse colon distention and pneumatosis intestinalis without mechanical obstruction, consistent with acute colonic pseudo-obstruction.

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Article Synopsis
  • - Intestinal pneumatosis is a rare condition, and its link to cetuximab, a cancer treatment drug, is even rarer.
  • - Documenting these unusual cases helps enhance clinical understanding and serves as a reference for future situations.
  • - Publishing this information may help doctors recognize and manage this complication earlier, improving patient care.
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Pneumatosis intestinalis (PI) and portal venous gas (PVG) are pathological conditions suggesting serious underlying diseases such as intestinal ischemia, intestinal wall infarction, and necrotizing enterocolitis. Therefore, early detection, comprehensive management, and timely treatment of the underlying disease are important for improving outcomes. We experienced a case of a patient who developed gangrenous cholecystitis secondary to PI and PVG.

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