AI Article Synopsis
- A new homodinuclear Co2/aminophenol sulfonamide complex has been created for the asymmetric Michael reaction, showing high efficiency with β-ketoesters and nitroolefins.
- The reaction demonstrates excellent results, achieving up to 99% yield and high enantioselectivity, remaining effective even on a larger 50 mmol scale.
- Mechanistic studies suggest that the Co2/2a complex is the active species driving the catalysis, leading to a proposed catalytic cycle.
Article Abstract
A homodinuclear Co2/aminophenol sulfonamide complex has been developed for the asymmetric Michael reaction of β-ketoesters with nitroolefins. This procedure is capable of tolerating a wide range of substrates and excellent results (up to 99% yield, >99 : 1 dr and 98% ee) can also be obtained. Moreover, the reaction could be carried out on a 50 mmol scale without any decrease in the enantioselectivity and reactivity. On the basis of the results of mechanistic studies, we proposed that the Co2/2a complex would be the active species and a possible catalytic cycle was described.
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| http://dx.doi.org/10.1039/c8ob00773j | DOI Listing |
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