Two Phase II studies, three Phase III and one observational study seem to justify that EMDA-MMC is a real alternative in the treatment of patients with NMIBC, especially the high risk group. The phase III studies compare EMDA-MMC with passive diffusion MMC and BCG in patients with bladder TIS. They showed EMDA MMC superiority compared to passive diffusion MMC and similar to BCG in achieving complete response at 3 and 6 months. In another randomized study on pT1 NMIBC patients, comparing a sequential scheme of BCG plus EMDA-MMC and BCG, the sequential regimen was significantly superior than BCG reducing recurrence and progression and improved overall and specific survivals. A third randomized study compared TURBT only with immediate post TURBT MMC instillation and EMDA-MMC preoperative instillation. This latter showed to be superior in recurrence prevention than the other two schemes. Tolerance to EMDA-MMC is inferior to passive diffusion MMC, but it does not reach statistical significance. In the same way, EMDA-MMC tolerance is better than BCG and there is no difference between this and the sequential scheme of BCG plus EMDA-MMC. Methodological defects observed in these studies and the fact that almost all of them come from the same group makes it necessary to reproduce this data in other centers so that this therapeutic alternative could be included in guidelines.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Prebiotics as modulators of colonic calcium and magnesium uptake.
Acta Physiol (Oxf)
February 2025
Institute for Molecular Medicine, Health and Medical University Potsdam, Potsdam, Germany.
Ca and Mg are essential nutrients, and deficiency can cause serious health problems. Thus, lack of Ca and Mg can lead to osteoporosis, with incidence rising both in absolute and age-specific terms, while Mg deficiency is associated with type II diabetes. Prevention via vitamin D or estrogen is controversial, and the bioavailability of Ca and Mg from supplements is significantly lower than that from milk products.
View Article and Find Full Text PDFInfluence of Formulation Composition on the Characteristic Properties of 5-fluorouracil-loaded Liposomes.
Turk J Pharm Sci
January 2025
Gazi University Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Türkiye.
Objectives: Variations in the types and quantities of excipients used to prepare liposomes can affect the physicochemical properties of liposome formulations. This study aimed to provide information about the design and fabrication of 5-fluorouracil (5-FU)-loaded liposome formulations using different lipid and cholesterol (CHOL) derivatives.
Materials And Methods: Passive loading via a small-volume incubation method was used to prepare liposomes.
Land-derived metals impact the survival and settlement of larval mussels.
Environ Pollut
January 2025
Cawthron Institute, 98 Halifax Street East, Nelson, 7010, New Zealand.
Global declines in wild mussel populations and production have been linked to the impacts of climate change and pollution. Summer die-offs of mussels (Perna canaliculus), spat retention issues, and a severe decline in mussel spat settlement have been reported in the Marlborough Sounds, an important area for mussel farming in New Zealand. Preliminary evidence suggests that naturally occurring contaminants and changing land use in the surrounding areas, could contribute to the decline of this species.
View Article and Find Full Text PDFSystematic Evaluation of Sampling Rate Influences and Variability in POCIS Using Meta-Analysis and Quantitative Structure Property Relationship (QSPR).
Environ Pollut
January 2025
Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Despite the significant benefits of aquatic passive sampling (low detection limits and time-weighted average concentrations), the use of passive samplers is impeded by uncertainties, particularly concerning the accuracy of sampling rates. This study employed a systematic evaluation approach based on the combination of meta-analysis and quantitative structure-property relationships (QSPR) models to address these issues. A comprehensive meta-analysis based on extensive data from 298 studies on the Polar Organic Chemical Integrative Sampler (POCIS) identified essential configuration parameters, including the receiving phase (type, mass) and the diffusion-limiting membrane (type, thickness, pore size), as key factors influencing uptake kinetic parameters.
View Article and Find Full Text PDFEnhancing Medical Student Engagement Through Cinematic Clinical Narratives: Multimodal Generative AI-Based Mixed Methods Study.
JMIR Med Educ
January 2025
Department of Medical Education, University of Idaho, 875 Perimeter Drive MS 4061, WWAMI Medical Education, Moscow, ID, 83844-9803, United States, 1 5092090908.
Background: Medical students often struggle to engage with and retain complex pharmacology topics during their preclinical education. Traditional teaching methods can lead to passive learning and poor long-term retention of critical concepts.
Objective: This study aims to enhance the teaching of clinical pharmacology in medical school by using a multimodal generative artificial intelligence (genAI) approach to create compelling, cinematic clinical narratives (CCNs).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!