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Assessing the kidney function parameters glomerular filtration rate and effective renal plasma flow with dynamic FDG-PET/MRI in healthy subjects. | LitMetric

AI Article Synopsis

  • A method was developed to assess kidney function, specifically glomerular filtration rate (GFR) and effective renal plasma flow (ERPF), using 2-deoxy-2-[F]fluoro-D-glucose (FDG) and PET scans, involving 24 healthy adults with dynamic PET/MRI imaging.
  • Results showed a strong correlation between the GFR and ERPF obtained from PET/MRI and traditional venous blood sample reference values, indicating accuracy in the method.
  • The study suggests that FDG PET/MRI can effectively evaluate kidney function during routine scans, potentially reducing the need for additional tests, but further research is needed to adapt this technique for PET/CT scans.

Article Abstract

Background: A method was developed to assess the kidney parameters glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) from 2-deoxy-2-[F]fluoro-D-glucose (FDG) concentration behavior in kidneys, measured with positron emission tomography (PET) scans. Twenty-four healthy adult subjects prospectively underwent dynamic simultaneous PET/magnetic resonance imaging (MRI) examination. Time activity curves (TACs) were obtained from the dynamic PET series, with the guidance of MR information. Patlak analysis was performed to determine the GFR, and based on integrals, ERPF was calculated. Results were compared to intra-individually obtained reference values determined from venous blood samples.

Results: Total kidney GFR and ERPF as estimated by dynamic PET/MRI were highly correlated to their reference values (r = 0.88/p < 0.0001 and r = 0.82/p < 0.0001, respectively) with no significant difference between their means.

Conclusions: The study is a proof of concept that GFR and ERPF can be assessed with dynamic FDG PET/MRI scans in healthy kidneys. This has advantages for patients getting a routine scan, where additional examinations for kidney function estimation could be avoided. Further studies are required for transferring this PET/MRI method to PET/CT applications.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943199PMC
http://dx.doi.org/10.1186/s13550-018-0389-1DOI Listing

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