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| http://dx.doi.org/10.1002/cre2.99 | DOI Listing |
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Emergency call utilization over a 10-years period: an observational study in Region Zealand, Denmark, 2013-2022.
Scand J Trauma Resusc Emerg Med
December 2024
Prehospital Center Region Zealand, Ringstedgade 61, 13., 4700, Næstved, Denmark.
Background: Improving prehospital emergency care requires a comprehensive understanding of the efficiency of emergency medical services and demand fluctuations. The medical emergency call is the primary contact between citizens and the emergency medical dispatch center, serving as the gateway to accessing emergency assistance. This study aimed to characterize the emergency call population and analyze the development of emergency call utilization in Region Zealand in Denmark during a 10-years period.
View Article and Find Full Text PDFDevelopment of Real-Time Surveillance for Serious Adverse Events in a Pragmatic Clinical Trial Using National Registers in Finland.
Clin Epidemiol
December 2024
Data and Analytics, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
Purpose: We developed a hybrid safety surveillance approach for a large, pragmatic clinical trial of a high-dose quadrivalent influenza vaccine (QIV-HD), using both active and passive data collection methods. Here, we present the methods and results for the passive register-based surveillance of serious adverse events (SAEs), which replaced conventional SAE reporting during the trial.
Patients And Methods: The trial recruited over 33,000 older adults of whom 50% received the QIV-HD while the rest received a standard-dose vaccine (QIV-SD) as a control vaccine.
Clinical features and treatment of stroke-like episodes in mitochondrial disease: a cohort-based study.
J Neurol
December 2024
Clinical Neurosciences, Department of Clinical Medicine, University of Turku, Turku, Finland.
Background: Stroke-like episode (SLE) is a subacute evolving brain syndrome in patients with primary mitochondrial diseases. Despite previous research, the understanding of the clinical spectrum, treatment, and outcomes of mitochondrial SLEs is far from complete. In this single centre study, we report the clinical symptoms and radiological findings as well as the medical treatment and outcomes of SLEs in patients with mitochondrial disease.
View Article and Find Full Text PDFReal-world effects of antidepressants for depressive disorder in primary care: population-based cohort study.
Br J Psychiatry
December 2024
Oxford Precision Psychiatry Lab, National Institute for Health and Care Research (NIHR) Oxford Health Biomedical Research Centre, Oxford, UK.
Background: Antidepressants' effects are established in randomised controlled trials (RCTs), but not in the real world.
Aims: To investigate real-world comparative effects of antidepressants for depression and compare them with RCTs.
Method: We performed a cohort study based on the QResearch database.
Contemporary menopausal hormone therapy and risk of cardiovascular disease: Swedish nationwide register based emulated target trial.
BMJ
November 2024
Department of Immunology, Genetics and Pathology, SciLifeLab, Uppsala University, Uppsala, Sweden
Objective: To assess the effect of contemporary menopausal hormone therapy on the risk of cardiovascular disease according to the route of administration and combination of hormones.
Design: Nationwide register based emulated target trial.
Setting: Swedish national registries.
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