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Discordant NIPT result in a viable trisomy-21 pregnancy due to prolonged contribution to cfDNA by a demised trisomy-14 cotwin. | LitMetric
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Discordant NIPT result in a viable trisomy-21 pregnancy due to prolonged contribution to cfDNA by a demised trisomy-14 cotwin.

Ron Hochstenbach Martin G Elferink Patrick H A van Zon Klaske D Lichtenbelt Jeske van Harssel Heleen Schuring-Blom Godelieve C M L Page-Christiaens

Clin Case Rep

Department of Obstetrics and Gynecology University Medical Centre Utrecht Utrecht The Netherlands.

Published: May 2018

One of the confounders in noninvasive prenatal testing (NIPT) is the vanishing twin phenomenon. Prolonged contribution to the maternal Cell-free DNA (cfDNA) pool by cytotrophoblasts representing a demised, aneuploid cotwin may lead to a false-positive outcome for a normal, viable twin. We show that a vanishing trisomy-14 twin contributes to cfDNA for more than 2 weeks after demise.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930198PMC
http://dx.doi.org/10.1002/ccr3.1424DOI Listing

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