AI Article Synopsis
Article Abstract
Background: Dengue fever is an important tropical infection causing significant mortality. The pathophysiology of hematological abnormalities in dengue remains poorly studied. In this study, we analyzed the hematological abnormalities by thromboelastography (TEG).
Methods: This cross-sectional study evaluated complicated dengue patients with TEG. Thromboelastographic variables were categorized into six patterns: factor deficiency, platelet dysfunction, enzymatic hypercoagulability, combined enzymatic and platelet hypercoagulability, primary fibrinolysis, and secondary hyperfibrinolysis.
Results: Twenty-five patients were analyzed for coagulation abnormalities by TEG. Coagulation factor deficiency pattern was noted in 11 patients (44%) whereas 3 patients (12%) were found to have low fibrinogen level pattern. Low platelet function was noted in 4 (16%) patients. Enzymatic hypercoagulability and combined enzymatic and platelet hypercoagulability were noted in one patient each (4.5%). Secondary fibrinolysis was noted in 1 patient (5%) and primary fibrinolysis in 3 (15.8%) patients. Factor deficiency pattern and low fibrinogen pattern were not significantly associated with hepatitis ( > 0.05). Activated partial thromboplastin time (aPTT) was not found to be significantly associated with factor deficiency pattern ( = 0.10) and low fibrinogen pattern ( = 0.20). Platelet count was not found to be significantly associated with platelet function ( = 0.54).
Conclusion: Factor deficiency pattern was the major abnormality noted in dengue patients followed by platelet dysfunction and primary fibrinolysis. Platelet count did not show significant association with platelet function. aPTT did not show significant association with factor deficiency and low fibrinogen patterns. Factor deficiency pattern and low fibrinogen pattern did not show significant association with hepatitis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930527 | PMC |
| http://dx.doi.org/10.4103/ijccm.IJCCM_486_17 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Phenotypic traits and family history in patients with 22q11.2 deletion syndrome and generalized epilepsy: A multicenter case-control study.
Epilepsia
December 2024
Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Objective: This study was undertaken to characterize the clinical and genetic features of patients with 22q11.2 deletion syndrome (22q11.2DS) and generalized epilepsy compared with 22q11.
View Article and Find Full Text PDFT-cadherin modulates adipogenic differentiation in mesenchymal stem cells: insights into ligand interactions.
Front Cell Dev Biol
December 2024
Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia.
Introduction: T-cadherin, a non-canonical member of the cadherin superfamily, was initially identified for its involvement in homophilic recognition within the nervous and vascular systems. Apart from its adhesive function, T-cadherin acts as a receptor for two ligands: LDL, contributing to atherogenic processes, and HMW adiponectin, a hormone with well-known cardiovascular protective properties. However, the precise role of T-cadherin in adipose tissue remains elusive.
View Article and Find Full Text PDFUnderstanding the development of tuberculous granulomas: insights into host protection and pathogenesis, a review in humans and animals.
Front Immunol
December 2024
Department of Academic Affairs, National Jewish Health, Denver, CO, United States.
Granulomas, organized aggregates of immune cells which form in response to (), are characteristic but not exclusive of tuberculosis (TB). Despite existing investigations on TB granulomas, the determinants that differentiate host-protective granulomas from granulomas that contribute to TB pathogenesis are often disputed. Thus, the goal of this narrative review is to help clarify the existing literature on such determinants.
View Article and Find Full Text PDFSimple prediction model for vitamin D deficiency in women with osteoporosis or risk factors for osteoporosis in Thailand.
J Clin Transl Endocrinol
December 2024
Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama 6 Road, Ratchathewi, Bangkok 10400, Thailand.
Introduction: In Thailand, the assessment of vitamin D status by measuring 25-hydroxyvitamin D[25(OH)D] levels in individuals at risk for osteoporosis is constrained by limited facilities and high costs. This study aimed to create a clinical model for predicting vitamin D deficiency in women with osteoporosis or risk factors for osteoporosis.
Materials And Methods: This was a cross-sectional study of 490 women.
Research on the pathways to high-quality development of tourism SMEs: A perspective of value assigned by quality, standards and brand.
Heliyon
December 2024
School of Management, Ocean University of China, Qingdao, People's Republic of China.
With the advancement of the United Nations Sustainable Development Goals, the trend toward sustainable and high-quality development has become prominent for tourism enterprises. Tourism small and medium-sized enterprises (SMEs), which are numerous, constitute a significant part of the global tourism market. However, existing research predominantly focuses on the pathways for high-quality development of large tourism enterprises, with many gaps in understanding the corresponding processes for tourism SMEs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!