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Two Cases of Crystal-storing Histiocytosis Diagnosed by Morphology, Immunohistochemistry, and Ultrastructural Examination.
Appl Immunohistochem Mol Morphol
January 2021
Department of Pathology, Anatomy, & Cell Biology, Thomas Jefferson University, Philadelphia, PA.
Crystal-storing histiocytosis (CSH) is a non-neoplastic histiocytic proliferation containing crystalline material, usually associated with an underlying lymphoproliferative or plasmacytic disorder. The crystalline structures are typically derived from kappa light chain immunoglobulins. The lesions of CSH are comprised of sheets of histiocytes with abundant eosinophilic cytoplasm containing variably prominent, elongated crystals.
View Article and Find Full Text PDFAbundant pseudo-Gaucher cells result in delay in diagnosis of plasma cell myeloma.
Br J Haematol
August 2018
Department of Haematology, Royal Free London NHS Foundation Trust, London, UK.
Abundant hepatic Gaucher-like cells following chemotherapy and bone marrow transplantation for hematologic malignancy: report of two cases.
Int J Surg Pathol
February 2013
Oregon Health & Science University, Portland, OR 97239, USA.
Cells with a resemblance to Gaucher cells, sometimes called pseudo-Gaucher cells, are seen in the bone marrow of some patients with hematologic malignancy or anemia. These cells are derived from cells of the monocytic lineage but do not show the characteristic inclusions of true Gaucher cells when examined by electron microscopy. Large numbers of Gaucher-like cells were found in the livers at autopsy of 2 patients with hematologic malignancy treated with chemotherapy and bone marrow transplant.
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