-abietane diterpenoids from Baill. (Euphorbiaceae), their cytotoxic and anticancer properties.

The stem bark extract of afforded a previously undescribed -abietane diterpenoid trivially named mangiolide () and a known jolkinolide B () via anticancer bioassay-guided fractionation. The CHCl:MeOH extract of was initially analysed for its anticancer properties against three cancer cell lines, renal (TK10), melanoma (UACC62), and breast (MCF7) and was found to be potent at low μg/mL ranges. Compound , 6α-acetoxy-14-keto--abieta-7(8),13(15)-diene-16,12-olide (mangiolide) inhibited the growth of renal (TK10) with a GI of 0.02 μg/mL; a GI of 0.03 μg/mL for melanoma (UACC62) and a GI of 0.05 μg/mL for breast (MCF7) cancer cell lines. Compound , 8,13-diepoxy-13,15--abietene-16,12-olide (jolkinolide B) inhibited the growth (GI) of the cell lines at 3.31 μg/mL for renal (TK10), 0.94 μg/mL for melanoma (UACC62) and 2.99 μg/mL for the breast (MCF7). The structures were established on the basis of their spectroscopic analysis and the absolute stereostructures assigned using electronic circular dichroism (ECD).