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Three new glycosides (-), together with six known ones (-), were isolated from the root bark of . Their structures were elucidated on the basis of MS and NMR spectroscopic data. Five compounds (, , , , and exhibited potent antihyperlipidemic activities in HepG2 cells as assessed by Oil Red O staining and significant inhibition of intracellular triglyceride (TG) levels, whereas two compounds ( and ) significantly reduced total cholesterol (TC) levels.
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http://dx.doi.org/10.1080/14786419.2018.1466125 | DOI Listing |
Phytochemistry
March 2025
School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu Province 211166, PR China. Electronic address:
This study reports the isolation of 11 previously undescribed sesquiterpenoids from the root bark of Lycium chinense Mill, including a 1,10-secoeudesmane-type sesquiterpene (1), a 9,10-secoeudesmane-type sesquiterpene (2) and nine rearranged eudesmane sesquiterpenes (3-11). Structures elucidation of these compounds was established using 1D/2D NMR, electronic circular dichroism calculations along with DP4 probability analysis, and X-ray diffraction analysis of single crystals. Lyciiterpenoid E (1), a eudesmane sesquiterpenoid, is characterised by a bond cleavage between C-1 and C-10 while, lyciiterpenoid F (2) exhibits a bond cleavage between C-9 and C-10.
View Article and Find Full Text PDFMed Int (Lond)
February 2025
Department of Pharmacology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast 00233, Ghana.
Paeonol a, pharmacologically active constituent obtained from the root bark of has been extensively utilized as a traditional Chinese medicine for the treatment, prevention and control of several diseases for years. Paeonol has been reported to possess key immunomodulatory properties; however, the underlying mechanisms involved in its immunomodulatory and anticancer effects have not been extensively researched due to limitations in terms of design, conduct and interpretation. The present review focuses on both the and immunosuppressive and anticancer effects of paeonol and the underlying mechanisms of action.
View Article and Find Full Text PDFEur J Pharmacol
March 2025
Puer Hospital of Traditional Chinese Medicine, Puer, Yunnan, China. Electronic address:
Background: The treatment of ulcerative colitis (UC) remains a huge challenge worldwide. Dictamnine is a natural product derived from Dictamnus dasycarpus Turcz. root bark and possesses multi-pharmacological properties, including anti-inflammation effects.
View Article and Find Full Text PDFNat Prod Res
March 2025
Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon.
The chemical investigations of the methanolic root, stem bark, leaf, and fruit extracts of Miq (Moraceae) led to the isolation of nineteen different compounds including one new triglyceride derivative named vogelianor (), two compounds ( and ) obtained for the first time from a natural source, as well as sixteen known compounds (-). The structures of all the isolates were established by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. Compound showed moderate activity against with a MIC value of 31.
View Article and Find Full Text PDFJ Chromatogr A
April 2025
School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China. Electronic address:
Fissistigma polyanthum is a renowned medicinal plant traditionally used by over 10 ethnic groups in China to treat various ailments, including inflammation. However, research on its chemical composition and bioactivity remains limited. This study investigated the chemical profiles and biological activities across different parts of F.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!