AI Article Synopsis
- The iron-catalyzed cycloaddition reaction successfully transforms alkene-tethered oxime esters and 1,2-disubstituted alkenes into tetrahydropyrrolizines, which are often found in bicyclic alkaloids.
- The process involves a two-step cyclization, starting with an intramolecular cyclization followed by an intermolecular one.
- The generation of an imine moiety is crucial for ensuring regioselectivity in the reaction.
Article Abstract
The iron-catalyzed cycloaddition reaction of alkene-tethered oxime esters with 1,2-disubstituted alkenes afforded tetrahydropyrrolizines, the structural motif often seen in bicyclic alkaloids. The reaction proceeds through consecutive cycloaddition reactions. These include, first, intramolecular cyclization, followed by intermolecular cyclization with a 1,2-disubstituted alkene in a regioselective manner where an imine moiety first generated plays a pivotal role.
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