We report a case of probable encephalitis presenting as narcolepsy with cataplexy, but with cyclical exacerbation and cognitive difficulties. Our patient continued to worsen despite treatment for narcolepsy and later was thought to have an immune-mediated encephalopathy. Treatment with intravenous gamma immunoglobulin (IVIG) led to complete recovery. Cyclic symptoms of narcolepsy with cataplexy are thus one presentation of probable immune-mediated encephalitis.
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http://dx.doi.org/10.1016/j.ensci.2018.01.003 | DOI Listing |
Ann Clin Transl Neurol
December 2024
Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Objectives: To explore the efficacy of ofatumumab in new onset narcolepsy type 1 following SARS-CoV-2 infection.
Methods: We present a 9-year-old girl who experienced new onset narcolepsy type 1 following SARS-CoV-2 infection. Polysomnography (PSG) followed by a daytime multiple sleep latency test (MSLT) was under taken after admission.
J Med Case Rep
December 2024
Ibn Sina Hospital, Kuwait, Kuwait.
Background: Sleep disorders are a common health problem that can be classified into many types that are distinguished by their history and characteristics. In this case report, we discuss a case of a patient suffering from recurrent unusual prolonged sleep attacks lasting up to 9 days that responded excellently to levetiracetam.
Case Presentation: An 18-year-old Syrian male patient presented to the neurology department complaining of recurrent prolonged sleep episodes lasting for 9 days.
medRxiv
December 2024
Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, School of Brain Science and Brain Medicine, and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, 310058, China.
We present the Large PSG Model (LPSGM), a unified and flexible framework for sleep staging and disease diagnosis using polysomnography (PSG) data. LPSGM is designed to address the challenges of cross-center generalization in sleep staging and to enable fine-tuning for downstream disease diagnosis tasks. LPSGM introduces a unified training framework for heterogeneous datasets and allows flexible channel input adjustments during inference.
View Article and Find Full Text PDFLancet Neurol
January 2025
National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome, Sleep-Wake Disorders Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, 34000 Montpellier, France; Institute of Neurosciences of Montpellier, INSERM, Montpellier, France. Electronic address:
Brain Res
December 2024
Geriatric Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China. Electronic address:
Since the discovery of orexin/hypocretin, numerous studies have accumulated evidence demonstrating its key role in various aspects of neuromodulation, including addiction, motivation, and arousal. This paper focuses on the projection of orexin neurons to specific target brain regions through distinct neural pathways to regulate sleep and arousal. We provide a detailed discussion of the projection mechanisms of orexin neurons to downstream neurons, particularly emphasizing their activation of monoaminergic and cholinergic neurons associated with arousal.
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