Increasing evidence suggests that microRNAs (miRNAs) play a crucial role in the pathogenesis of tumor. In this study, miR-214 was found to be significantly down-regulated in lung tumor tissues and lung cell lines. From the gain-of-function experiment results, we found that ectopic expression of miR-214 in lung cancer cell lines significantly inhibited cell growth, as evidenced by cell viability and colony formation assays, and suppressed tumor growth in . Besides, further investigations showed that miR-214 inhibited cell migration and invasion. The luciferase activity assay revealed that oncogene Janus kinase 1 (JAK1) was a direct target gene of miR-214, and its expression was inversely correlated with that of miR-214. Altogether, our findings demonstrated that miR-214 plays a pivotal role in lung cancer by inhibiting cell proliferation, invasion and migration by targeting oncogenic JAK1, and thus, miR-214 may provide a new potential therapeutic target in lung cancer.
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