AI Article Synopsis
- Murrayaquinones A-D are four bioactive compounds derived from the root bark of the plant Hayata.
- The synthesis of Murrayaquinone involves five steps starting from 2,4,5-trimethoxybenzaldehyde, achieving a total yield of 45%.
- A key innovation in this synthesis is the use of a manganese acetate-mediated oxidative radical reaction to help form the indole ring in the final stages.
Article Abstract
Murrayaquinones A-D is a group of four bioactive carbazole-1,4-dione natural products isolated from the root bark of the plant hayata. Murrayaquinone is synthesized in five steps starting from the commercially available 2,4,5-trimethoxybenzaldehyde with an overall yield of 45%. The novelty of this murrayaquinone synthesis is in the use of a Mn(OAc) mediated oxidative radical reaction of a N-benzylaminoquinone derivative with 2-cyclohexen-1-one for the late-stage indole ring construction.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935454 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2018.01.007 | DOI Listing |
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