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Compatibility of Active Pharmaceutical Ingredients in Cleoderm™: A Comprehensive Study for Enhanced Topical Dermatological Treatments.
Int J Pharm Compd
October 2024
Fagron BV, Rotterdam, The Netherlands.
Article Synopsis
- The study analyzes the stability and compatibility of active pharmaceutical ingredients in Cleoderm™, a cream aimed at treating various skin conditions like acne and dermatitis.
- Advanced methods like high-performance liquid chromatography (HPLC) were used to ensure that the ingredients maintain their efficacy under stress.
- Results showed that key ingredients remained stable over a designated shelf life of 180 days, confirming Cleoderm™ as a reliable option for customized dermatological therapies.
From Psychiatric Care to Dermatologic Dilemmas: A Case Report of Risperidone-Induced Bullous Pemphigoid.
Cureus
September 2024
Psychiatry, All India Institute of Medical Sciences, Gorakhpur, Gorakhpur, IND.
Article Synopsis
- - The patient is a 64-year-old male with a long history of delusional disorder, first showing symptoms at age 34, which were managed successfully for years until a relapse occurred.
- - Initial treatment with amisulpride failed, and risperidone caused severe skin reactions leading to a diagnosis of bullous pemphigoid, prompting a switch to other medications.
- - The introduction of aripiprazole and melatonin resulted in improved management of both delusional symptoms and the skin condition, illustrating the importance of monitoring for drug-induced side effects in elderly patients on antipsychotics.
Development, Pharmacokinetics and Antimalarial Evaluation of Dose Flexible 3D Printlets of Dapsone for Pediatric Patients.
AAPS PharmSciTech
September 2024
Texas A&M Health Science Center, Irma Lerma Rangel School of Pharmacy, Texas A&M University, Reynolds Medical Sciences Building, Suite 308, College Station, Texas, 77843, USA.
The focus of current studies was to fabricate dose flexible printlets of dapsone (DDS) for pediatric patients by selective laser sintering (SLS) 3D printing method, and evaluate its physicochemical, patient in-use stability, and pharmacokinetic attributes. Eight formulations were fabricated using Kollicoat IR, Eudragit L-100-55 and StarCapas excipients and evaluated for hardness, disintegration, dissolution, amorphous phase by differential scanning calorimetry and X-ray powder diffraction, in-use stability at 30 C/75% RH for a month, and pharmacokinetic study in Sprague Dawley rats. The hardness, and disintegration of the printlets varied from 2.
View Article and Find Full Text PDFFlavone Cocrystals: A Comprehensive Approach Integrating Experimental and Virtual Methods.
Cryst Growth Des
May 2024
Institute of Pharmacy, University of Innsbruck, Innrain 52c, 6020 Innsbruck, Austria.
Article Synopsis
- - The study explored the dapsone/flavone cocrystal system as a benchmark and expanded to sulfanilamide and sulfaguanidine, investigating how structural differences affect cocrystal formation.
- - Experimental methods included various mechanical and thermal techniques, while virtual screening assessed properties like molecular compatibility and hydrogen-bond potential, confirming the ability of all three APIs to form cocrystals with flavone.
- - Various cocrystals were identified, including novel enantiotripically related forms for sulfaguanidine, but despite exhaustive techniques, sulfanilamide did not yield a cocrystal; dapsone's stability with flavone was linked to strong interaction strengths.
Concordance of vacuum compression molding with spray drying in screening of amorphous solid dispersions of itraconazole.
Int J Pharm
April 2024
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, United States. Electronic address:
Spray drying is a well-established method for screening spray dried dispersions (SDDs) but is material consuming, and the amorphous solid dispersions (ASDs) formed have low bulk density. Vacuum Compression Molding (VCM) is a potential method to avoid these limitations. This study focuses on VCM to screen ASDs containing itraconazole and L, M, or H polymer grades of hydroxypropyl methylcellulose acetate succinate (HPMCAS) and compares their morphology, amorphous stability, and dissolution performance with spray drying.
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