AI Article Synopsis
- Senescence, or the aging process of leaves, is regulated by changing networks of interactions among specific transcription factors called NACs over time.
- A key finding is that at an advanced stage before senescence, these networks shift from promoting to inhibiting senescence, driven by a group of three NACs known as the "NAC troika."
- Research shows that disrupting this NAC troika speeds up senescence, while enhancing its activity delays it; these NACs also work to suppress processes that promote aging, like responses to salicylic acid and reactive oxygen species.
Article Abstract
Senescence is controlled by time-evolving networks that describe the temporal transition of interactions among senescence regulators. Here, we present time-evolving networks for NAM/ATAF/CUC (NAC) transcription factors in during leaf aging. The most evident characteristic of these time-dependent networks was a shift from positive to negative regulation among NACs at a presenescent stage. ANAC017, ANAC082, and ANAC090, referred to as a "NAC troika," govern the positive-to-negative regulatory shift. Knockout of the NAC troika accelerated senescence and the induction of other s, whereas overexpression of the NAC troika had the opposite effects. Transcriptome and molecular analyses revealed shared suppression of senescence-promoting processes by the NAC troika, including salicylic acid (SA) and reactive oxygen species (ROS) responses, but with predominant regulation of SA and ROS responses by ANAC090 and ANAC017, respectively. Our time-evolving networks provide a unique regulatory module of presenescent repressors that direct the timely induction of senescence-promoting processes at the presenescent stage of leaf aging.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003463 | PMC |
| http://dx.doi.org/10.1073/pnas.1721523115 | DOI Listing |
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Proc Natl Acad Sci U S A
May 2018
Center for Plant Aging Research, Institute for Basic Science (IBS), Daegu 42988, Republic of Korea;
Article Synopsis
- Senescence, or the aging process of leaves, is regulated by changing networks of interactions among specific transcription factors called NACs over time.
- A key finding is that at an advanced stage before senescence, these networks shift from promoting to inhibiting senescence, driven by a group of three NACs known as the "NAC troika."
- Research shows that disrupting this NAC troika speeds up senescence, while enhancing its activity delays it; these NACs also work to suppress processes that promote aging, like responses to salicylic acid and reactive oxygen species.
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