The interaction of natamycin-azithromycin combination against 60 ocular fungal isolates was tested The combination produced 100% synergistic interactions when natamycin was added to azithromycin 20, 40, and 50 μg/ml against species complex (AFSC) isolates and to azithromycin 50 μg/ml against species complex isolates. Addition of 50 μg/ml azithromycin enhanced natamycin's effect against AFSC isolates by reducing natamycin MIC from 64 to 0.031 μg/ml. No antagonism was observed.
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| http://dx.doi.org/10.1128/AAC.00077-18 | DOI Listing |
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