Livestock-associated methicillin-resistant (LA-MRSA) isolates are increasingly migrating from livestock into human and animal health care settings. Alternative substances are needed to overcome the drawbacks of currently available drugs used for MRSA eradication. The recombinant bacteriophage endolysin HY-133 has proved to be an active agent against Here, the activity of HY-133 was studied against a large collection of genetically diverse LA-MRSA isolates revealing its high activity against -, -, and -positive LA-MRSA.
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http://dx.doi.org/10.1128/AAC.00385-18 | DOI Listing |
J Glob Antimicrob Resist
December 2024
Department of Hygiene, Sapporo Medical University School of Medicine, Hokkaido, Sapporo 060-8556, Japan. Electronic address:
Objectives: Staphylococcus aureus is a major cause of bloodstream infections. The recent epidemiological features and antimicrobial resistance trend were analyzed for methicillin-resistant and susceptible S. aureus (MRSA/MSSA) isolates from blood samples in northern Japan.
View Article and Find Full Text PDFMicrobiol Spectr
January 2025
Area of Biochemistry and Molecular Biology, OneHealth-UR Research Group, University of La Rioja, Logroño, Spain.
Unlabelled: Livestock-associated methicillin-resistant (LA-MRSA), such as clonal-complex (CC)398, are of clinical relevance due to their multi-drug resistance profiles, adding to the overall burden of MRSA in humans. The objective was to evaluate the double-zone hemolysis (DZH) test as a simple and reliable method for detecting LA-MRSA in the clinical microbiology laboratory. isolates assigned to CC398 ( = 183; 152 MRSA/31 methicillin-susceptible [MSSA]), CC1 ( = 44; MRSA), and other CCs ( = 144; 94 MRSA/50 MSSA) were investigated.
View Article and Find Full Text PDFInfect Genet Evol
December 2024
Duke-Ruhuna Collaborative Research Centre, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; Duke Global Health Institute, Durham, NC, USA; Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.
Vet Sci
November 2024
SEGES Innovation P/S, Agro Food Park 15, 8200 Aarhus, Denmark.
Livestock-associated methicillin-resistant (LA-MRSA) is widespread in European pig production and poses an occupational hazard to farm workers and their household members. Farm workers are exposed to LA-MRSA through direct contact with pigs and airborne transmission, enabling bacteria to be carried home in the nose or on the skin. Consequently, it is important to consider LA-MRSA in a one-health context, studying human exposure by examining LA-MRSA levels in pigs, air, and dust in the farm environment.
View Article and Find Full Text PDFOpen Vet J
September 2024
Department of Microbiology and Parasitology, Faculty of Veterinary Medicine, Universitas Pendidikan Mandalika, Mataram, Indonesia.
The livestock-associated methicillin-resistant (LA-MRSA) strains are prevalent in the poultry farming environment and are a common component of the bacterial microbiota on the skin and mucous membranes of healthy animals. The origin and spread of LA-MRSA are attributed to the use of antibiotics in animals, and close contact between people and different animal species increases the risk of animal exposure to humans. The epidemiology of LA-MRSA in poultry significantly changed when ST398 and ST9 were found in food-producing animals.
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