Purpose Of Investigation: To determine a cut-off value for beta-human chorionic gonadotropin (β-hCG) concentrations to predict dizygotic twinning after in vitro fertilization (IVF) and double embryo transfer (DET).
Materials And Methods: This retrospective cohort study included 233 women who conceived after DET at IVF center, Hacettepe University Faculty of Medicine. Patients with serum P-hCG concentration 25 IU/l assayed on day 14 after oocyte retrieval were included into the study.
Results: Lower serum β-hCG concentrations were observed in non-viable pregnancy when compared to their viable counterparts. In addition, twins exhibited higher 0- hCG concentrations than singletons did. Receiver operator characteristic (ROC) curve analysis showed a significant relationship between serum βhCG concentrations and the occurrence of twin pregnancy (area under the curve = 0.85, 95% confidence interval = 0.79-0.91, p < 0.001). For twin pregnancy, when β-hCG ≥ 175 IU/l, sensitivity was 77.3%, specificity was 80.0%, positive predictive value (PPV) was 48.2%, and negative predictive value (NPV) was 93.8%.
Conclusion: P-hCG > 175 IU/I might be used as a new cut-off value for early prediction of viable dizygotic twins following IVF-DET treatment cycles.
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