Background: Urethral warmer and cryoheater are invented and applied in cryoablation to overcome urethral cryoinjury, but these devices cannot be fixed and precisely control the released heat which excessively reduces the effective ablation area. Current warmers enlarge the operation difficulty and decrease the precision in temperature control.
Objective: A reformed catheter termed urethral heater aims to protect the urethra and simultaneously control the released heat so as to meet the aid of doctors' convenient operation in effective therapy, device fixation and precise heat controllability.
Materials And Methods: In this paper, the temperature controller combined with temperature monitor was used to control the heating behavior of the urethral heater with the initial active temperature. The controllability and thermal protection of the urethral heater was simulated and tested, which compared with that of urethral warmer.
Results: During the trials in vitro, the lowest temperature at the urethra surface is -3.7 degree C when one cryoprobe was introduced in the cryoablation for 15 min and -15.3 degree C with two cryoprobes. Above all, the effective cryoablation area increased with the decline of initial active temperatures.
Conclusion: The urethral heater is able to prevent the urethra from irreversible damage and modulate the ablation area. The delay of heat is a new way to decline the recurrence rate and facilitate the desire of aconuresis during the cryoablation.
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Cryo Letters
June 2018
Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and MolecularEngineering, East China University of Science and Technology, Shanghai, China.
Background: Urethral warmer and cryoheater are invented and applied in cryoablation to overcome urethral cryoinjury, but these devices cannot be fixed and precisely control the released heat which excessively reduces the effective ablation area. Current warmers enlarge the operation difficulty and decrease the precision in temperature control.
Objective: A reformed catheter termed urethral heater aims to protect the urethra and simultaneously control the released heat so as to meet the aid of doctors' convenient operation in effective therapy, device fixation and precise heat controllability.
Phys Med Biol
August 2007
Biothermal Technology Laboratory, Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
As a part of an ongoing effort to develop computerized planning tools for cryosurgery, an experimental study has been conducted to verify a recently developed numerical technique for bioheat transfer simulations. Experiments were performed on gelatin solution as a phantom material, using proprietary liquid-nitrogen cryoprobes. Urethral warming was simulated with the application of a cryoheater, which is a proprietary temperature-controlled electrical heater.
View Article and Find Full Text PDFTechnol Cancer Res Treat
June 2004
Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
In a typical minimally invasive cryoprocedure, multiple cryoprobes are inserted into the tissue with the goal of maximizing cryoinjury within a predefined target region, while minimizing cryoinjury to the surrounding tissues. A temperature-controlled electrical heater has been developed recently by this research team, in order to assist in limiting the cryoinjury to the target region. The new device has been termed a 'cryoheater,' and it can work with any cryosurgical cooling technique.
View Article and Find Full Text PDFCryo Letters
April 2003
Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
The heating effect of urethral warming during cryosurgery has been investigated theoretically, via heat transfer simulations. Two warmer configurations have been considered: (i). the clinically available urethral warmer, which has a configuration of a counter flow fluid heat exchanger; (ii).
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