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| http://dx.doi.org/10.1371/journal.pcbi.1006139 | DOI Listing |
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Tenofovir and Doravirine Are Potential Reverse-Transcriptase Analogs in Combination with the New Reverse-Transcriptase Translocation Inhibitor (Islatravir) Among Treatment-Experienced Patients in Cameroon: Designing Future Treatment Strategies for Low- and Middle-Income Countries.
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Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon.
Islatravir (ISL) is a novel antiretroviral that inhibits HIV-1 reverse transcriptase translocation. The M184V mutation, known to reduce ISL's viral susceptibility in vitro, could arise from prolonged exposure to nucleoside reverse transcriptase inhibitors (NRTI) (3TC). This study evaluated the predictive efficacy of ISL and identified potentially active antiretrovirals in combination among treatment-experienced patients in Cameroon, where NRTIs (3TC) have been the backbone of ART for decades now.
View Article and Find Full Text PDFThe Impact of Antiretroviral Therapy on Liver Function Among Pregnant Women Living with HIV in Co-Existence with and Without Pre-Eclampsia.
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Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, Florida Campus, Roodepoort 1709, South Africa.
Pregnant women living with HIV (PWLWHIV) are at an increased risk of developing obstetrics complications such as pre-eclampsia (PE). Antiretroviral therapy (ART) remains the standard treatment for PWLWHIV and non-pregnant women. However, its use has been associated with adverse liver conditions, particularly hepatotoxicity, often marked by elevated liver enzymes (LEEs) as demonstrated by an increased aspartate transferase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) in PWLWHIV on ART.
View Article and Find Full Text PDFEvaluating Spherical Trees in the Urban Environment in Budapest (Hungary).
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Department of Landscape Protection and Reclamation, Institute of Landscape Architecture, Urban Planning and Garden Art, Hungarian University of Agriculture and Life Sciences, 1118 Budapest, Hungary.
The world's big cities, including Budapest, are becoming more crowded, with more and more people living in smaller and smaller spaces. There is an increasing demand for more green space and trees, with less vertical and less horizontal space. In addition, deteriorating environmental conditions are making it even more difficult for trees to grow and survive.
View Article and Find Full Text PDFEnhancing Acclimatization Conditions for 'Fire': A Comparative Analysis of Substrate Effects on Growth and Survival.
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Department of Floriculture and Dendrology, Institute of Landscape Architecture, Urban Planning and Garden Art, Hungarian University of Agriculture and Life Sciences (MATE), Villányi Street 29-43, 1118 Budapest, Hungary.
This study investigates the acclimatization success of 'Fire', a popular ornamental bromeliad, through in vitro propagation on various substrates. Due to the increasing demand for , micropropagation offers a promising solution to overcome the limitations of traditional propagation methods. In this research, acclimatization was conducted in two trial types: in the one-step greenhouse conditions, and in two-step acclimatization, which introduced a controlled laboratory step before transferring plants to the greenhouse.
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Department of Computer Engineering, Inje University, Gimhae 50834, Republic of Korea.
Background: Food image recognition, a crucial step in computational gastronomy, has diverse applications across nutritional platforms. Convolutional neural networks (CNNs) are widely used for this task due to their ability to capture hierarchical features. However, they struggle with long-range dependencies and global feature extraction, which are vital in distinguishing visually similar foods or images where the context of the whole dish is crucial, thus necessitating transformer architecture.
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