AI Article Synopsis
- In congenital adrenal hyperplasia (CAH), children and adolescents display high rates of obesity and increased levels of metabolic risk factors, including hyperinsulinemia and leptin.
- A study of 40 patients revealed that 50% were obese or overweight, with notable prevalence of hypertriglyceridemia and other cardiometabolic issues.
- Leptin levels were strongly correlated with body fat percentage, BMI, and the number of cardiometabolic risk factors, suggesting that elevated leptin may indicate a worse metabolic profile in these individuals.
Article Abstract
Introduction: In congenital adrenal hyperplasia (CAH), obesity, hyperinsulinemia and leptin levels are increased.
Objective: To identify the frequency of cardiometabolic risk factors (CRF) in children and adolescents with CAH and to explore the relationship with leptin levels.
Method: Cross-sectional study of 40 patients who underwent anthropometric measurements and had fasting glucose, insulin, triglycerides, 17-hidroxyprogesterone, leptin, HDL and LDL-cholesterol assessed. The patients were classified according to the number of CRFs, and leptin levels were analyzed with the Kruskal-Wallis test. Pearson's correlation was applied between leptin, body mass index (BMI) z-score and body fat percentage.
Results: Fifty percent of the patients had obesity and overweight, 59% had hypertriglyceridemia, 40%, hypoalphalipoproteinemia, 27.5%, high LDL-cholesterol and 22.5% insulin resistance. There was positive correlation between leptin and body fat percentage (r = 0.64), BMI z-score (r = 0.55) and the number of CRFs (r = 0.65). In the obesity-adjusted multivariate analysis, leptin levels were associated with the number of CRFs.
Conclusion: CAH had a high frequency of CRFs and leptin appeared to be associated with a more adverse cardiometabolic profile in subjects with obesity and overweight.
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| http://dx.doi.org/10.24875/GMM.18002952 | DOI Listing |
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