AI Article Synopsis
- A new nickel-catalyzed reaction for enantioselective allylic alkylation has been developed, focusing on lactone and lactam substrates.
- The process uses a readily available chiral bisphosphine ligand and achieves good yields and high enantioselectivity (up to 90% ee) with various unactivated allylic alcohols.
- The method's versatility is demonstrated by its successful application in creating synthetically valuable products.
Article Abstract
The first nickel-catalyzed enantioselective allylic alkylation of lactone and lactam substrates to deliver products bearing an all-carbon quaternary stereocenter is reported. The reaction, which utilizes a commercially available chiral bisphosphine ligand, proceeds in good yield with a high level of enantioselectivity (up to 90% ee) on a range of unactivated allylic alcohols for both lactone and lactam nucleophiles. The utility of this method is further highlighted a number of synthetically useful product transformations.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912103 | PMC |
| http://dx.doi.org/10.1039/c7sc05216b | DOI Listing |
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