AI Article Synopsis
- Halogenation improves the effectiveness of potential pharmaceuticals by enhancing their potency in medicinal chemistry.
- Halogenases, evolved enzymes, effectively perform selective halogenation reactions under mild conditions, addressing challenges of traditional synthetic methods.
- Recent advancements in halogenase biocatalysts show promise for industrial use, offering a wide range of applications in drug development due to their stability and versatility with various substrates.
Article Abstract
Halogenation is commonly used in medicinal chemistry to improve the potency of pharmaceutical leads. While synthetic methods for halogenation present selectivity and reactivity challenges, halogenases have evolved over time to perform selective reactions under benign conditions. The optimization of halogenation biocatalysts has utilized enzyme evolution and structure-based engineering alongside biotransformation in a variety of systems to generate stable site-selective variants. The recent improvements in halogenase-catalyzed reactions has demonstrated the utility of these biocatalysts for industrial purposes, and their ability to achieve a broad substrate scope implies a synthetic tractability with increasing relevance in medicinal chemistry.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964047 | PMC |
| http://dx.doi.org/10.1016/j.bmcl.2018.04.066 | DOI Listing |
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