AI Article Synopsis
- * The nanoparticles are coated with anti-VEGF antibodies and designed to deliver doxorubicin more effectively to tumor cells, specifically in a mouse model of breast cancer.
- * Results showed that mice treated with these targeted nanoparticles had a 50% increase in median survival, and MRI confirmed that the nanoparticles accumulated in the tumors, enabling dual therapy and imaging.
Article Abstract
In presented paper we have developed new system for cancer theranostics based on vascular endothelial growth factor (VEGF) targeted magnetic nanoparticles. Conjugation of anti-VEGF antibodies with bovine serum albumin coated PEGylated magnetic nanoparticles allows for improved binding with murine breast adenocarcinoma 4T1 cell line and facilitates doxorubicin delivery to tumor cells. It was shown that intravenous injection of doxorubicin loaded VEGF targeted nanoparticles increases median survival rate of mice bearing 4T1 tumors up to 50%. On the other hand magnetic resonance imaging (MRI) of 4T1 tumors 24 h after intravenous injection showed accumulation of nanoparticles in tumors, thus allowing simultaneous cancer therapy and diagnostics.
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| http://dx.doi.org/10.1016/j.nano.2018.04.019 | DOI Listing |
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