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The Efficacy of Bepotastine Besilate Compared With Hydroxyzine Pamoate for Preventing Infusion Reactions to the First Dose of Rituximab in Patients With Non-Hodgkin Lymphoma: Protocol for a Phase II, Double-Blind, Multicenter Randomized Trial.
JMIR Res Protoc
February 2024
Department of Pharmacy, Kobe University Hospital, Kobe, Japan.
Background: Rituximab, an anti-CD20 monoclonal antibody, can cause infusion reactions (IRs), especially during the initial rituximab infusion therapy. Generally, patients are administered a histamine H-receptor antagonist before the rituximab infusion, along with an antipyretic analgesic, to prevent or reduce IRs. Multiple retrospective case-control studies indicate that the second generation of histamine H-receptor antagonists might be more effective than the first generation in suppressing IRs caused by the rituximab infusion.
View Article and Find Full Text PDFEfficacy and Toxicity Evaluation of Bepotastine Besilate 1.5% Preservative-Free Eye Drops Vs Olopatadine Hydrochloride 0.2% Bak-Preserved Eye Drops in Patients with Allergic Conjunctivitis.
Clin Ophthalmol
November 2023
Ocular Surface Service, Lomas de San Isidro Medical Group, Buenos Aires, Argentina.
Purpose: To study the efficacy and toxic effects of bepotastine besilate 1.5% preservative-free (BB-PF) and olopatadine 0.2% BAK-preserved (OL-BAK) drops on the ocular surface of patients with allergic conjunctivitis.
View Article and Find Full Text PDFComparative study on the efficacy and safety of bepotastine besilate versus levocetirizine in chronic spontaneous urticaria: A randomised, open-label, parallel study.
Indian J Dermatol Venereol Leprol
November 2023
Department of Pharmacology, Sri Ramachandra Medical College & Research Institute, Chennai, Tamil Nadu, India.
Background Urticaria is a common skin disease which often causes impairment in the quality of life. The ideal drug for chronic urticaria would have antihistaminic and anti-inflammatory actions. Bepotastine besilate is a recently approved novel anti-allergic agent with multiple mechanisms of action; levocetirizine is a potent and selective second-generation H1 receptor antagonist used in the treatment of urticaria.
View Article and Find Full Text PDFAn Investigator-Blind Randomized Controlled Trial Comparing Effectiveness, Safety of Levocetirizine and Bepotastine in Chronic Urticaria.
Indian J Dermatol
January 2021
Department of Dermatology, Bankura Sammilani Medical College, Kenduadihi, Bankura, West Bengal, India.
Article Synopsis
- Chronic urticaria is a common skin condition that causes discomfort, and there is a need for more effective treatment options like bepotastine, a second-generation antihistamine that may also help reduce eosinophil migration.
- A study was conducted to compare the effectiveness and safety of bepotastine and levocetirizine in treating chronic urticaria, involving adult patients randomly assigned to either medication over multiple follow-ups.
- Results showed that both medications reduced urticaria severity scores, but bepotastine had a significantly lower incidence of daytime sedation compared to levocetirizine, suggesting it might be a better option for patients concerned about side effects.
Efficacy and safety of rupatadine fumarate in the treatment of perennial allergic rhinitis: A multicenter, double-blinded, randomized, placebo-controlled, bridging study in Koreans.
Asian Pac J Allergy Immunol
December 2024
Department of Otorhinolaryngology-Head & Neck Surgery, Seoul National University Hospital, Seoul, Korea.
Background: The efficacy of rupatadine for the treatment of AR has been confirmed in numerous clinical studies, however there are very few studies on asian patients.
Objective: To assess the safety and efficacy of rupatadine fumarate in the treatment of Korean perennial allergic rhinitis (PAR) patients.
Methods: A multicenter, double-blind, randomized, placebo-controlled, comparative study of rupatadine fumarate and bepotastine besilate was conducted.
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