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pH-Triggered release of an antifungal agent from polyglycidol-based nanoparticles against fuel fungus H. resinae. | LitMetric

pH-Triggered release of an antifungal agent from polyglycidol-based nanoparticles against fuel fungus H. resinae.

J Colloid Interface Sci

CNRS UMR5629, Laboratoire de Chimie des Polymères Organiques, IPB-ENSCBP, Université de Bordeaux, 16 av Pey Berland, F-33607 Pessac, France. Electronic address:

Published: September 2018

AI Article Synopsis

  • * These particles were made using a specific polymerization technique and were designed to be sensitive to pH levels, using an imine bond to link the biocide.
  • * The research also included testing the antifungal effectiveness of the particles and their compatibility with a commercial coating to ensure their protective qualities remained intact.

Article Abstract

The goal of this investigation was the development of smart plurifunctional polymeric particles able to deliver a biocide following an acidic trigger due to the presence of microorganisms. Such particles were synthesized by Ring-Opening Metathesis Polymerization of an α-norbornenyl polyglycidol macromonomer functionalized with biocide through a pH-sensitive imine bond. H. resinae was selected as a target strain. In the first part, the pH sensitivity of the functionalized particles was studied. Then, the antifungal activity of both the biocide-functionalized macromonomer and the functionalized particles was evaluated. Incorporation of the particles in a commercial model coating was also tested, to verify that its original barrier properties were maintained.

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Source
http://dx.doi.org/10.1016/j.jcis.2018.03.106DOI Listing

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