Breaking the symmetry of electromagnetic wave propagation enables important technological functionality. In particular, circulators are nonreciprocal components that can route photons directionally in classical or quantum photonic circuits and offer prospects for fundamental research on electromagnetic transport. Developing highly efficient circulators thus presents an important challenge, especially to realise compact reconfigurable implementations that do not rely on magnetic fields to break reciprocity. We demonstrate optical circulation utilising radiation pressure interactions in an on-chip multimode optomechanical system. Mechanically mediated optical mode conversion in a silica microtoroid provides a synthetic gauge bias for light, enabling four-port circulation that exploits tailored interference between appropriate light paths. We identify two sideband conditions under which ideal circulation is approached. This allows to experimentally demonstrate ~10 dB isolation and <3 dB insertion loss in all relevant channels. We show the possibility of actively controlling the circulator properties, enabling ideal opportunities for reconfigurable integrated nanophotonic circuits.
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http://dx.doi.org/10.1038/s41467-018-04202-y | DOI Listing |
Sci Rep
January 2025
Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland.
Optical techniques, such as functional near-infrared spectroscopy (fNIRS), contain high potential for the development of non-invasive wearable systems for evaluating cerebral vascular condition in aging, due to their portability and ability to monitor real-time changes in cerebral hemodynamics. In this study, thirty-six healthy adults were measured by single channel fNIRS to explore differences between two age groups using machine learning (ML). The subjects, measured during functional magnetic resonance imaging (fMRI) at Oulu University Hospital, were divided into young (age ≤ 32) and elderly (age ≥ 57) groups.
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January 2025
Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.
The aberrant vascular response associated with tendon injury results in circulating immune cell infiltration and a chronic inflammatory feedback loop leading to poor healing outcomes. Studying this dysregulated tendon repair response in human pathophysiology has been historically challenging due to the reliance on animal models. To address this, our group developed the human tendon-on-a-chip (hToC) to model cellular interactions in the injured tendon microenvironment; however, this model lacked the key element of physiological flow in the vascular compartment.
View Article and Find Full Text PDFMolecules
January 2025
Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China.
In recent years, the near-infrared (NIR) fluorescence theranostic system has garnered increasing attention for its advantages in the simultaneous diagnosis- and imaging-guided delivery of therapeutic drugs. However, challenges such as strong background fluorescence signals and rapid metabolism have hindered the achievement of sufficient contrast between tumors and surrounding tissues, limiting the system's applicability. This study aims to integrate the pegylation strategy with a tumor microenvironment-responsive approach.
View Article and Find Full Text PDFLife (Basel)
December 2024
Department of Ophthalmology, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", University Street, No. 16, 700115 Iasi, Romania.
Numerous conditions, both physiological and pathological, can influence changes in the retinal vascular architecture. In order to be able to highlight pathological aspects of systemic diseases with ocular activity, it is necessary to understand how physiological fluctuations can influence circulation at the retinal level. The present study attempts to evaluate retinal and choroidal vascular and structural changes in healthy female subjects over the course of a menstrual cycle using OCT-A.
View Article and Find Full Text PDFMicromachines (Basel)
January 2025
Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
This paper presents, for the first time, a rotary actuator functionalized by an inclined disc rotor that serves as a distal optical scanner for endoscopic probes, enabling side-viewing endoscopy in luminal organs using different imaging/analytic modalities such as optical coherence tomography and Raman spectroscopy. This scanner uses a magnetic rotor designed to have a mirror surface on its backside, being electromagnetically driven to roll around the cone-shaped hollow base to create a motion just like a precessing coin. An optical probing beam directed from the probe's optic fiber is passed through the hollow cone to be incident and bent on the back mirror of the rotating inclined rotor, circulating the probing beam around the scanner for full 360° sideway imaging.
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