In this paper the properties of thermosensitive chitosan hydrogels, formulated with chitosan chloride with β-glycerophosphate disodium salt hydrate and chitosan chloride with β-glycerophosphate disodium salt hydrate enriched with calcium glycerophosphate, are presented. The study focused on the determination of the hydrogel structure after conditioning in water. The structure of the gels was investigated by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The crystallinity of the gel structure was determined by X-ray diffraction analysis (XRD) and the thermal effects were determined based on DSC thermograms.
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http://dx.doi.org/10.1016/j.saa.2018.04.050 | DOI Listing |
Acta Biomater
January 2025
Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, PR China; National-local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, Jilin, PR China; International Center of Future Science, Jilin University, Changchun, Jilin, PR China; State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, Jilin, PR China. Electronic address:
Tumor-associated macrophages (TAMs) significantly influence the clinical outcomes of immune checkpoint blockade (ICB) therapy. Strategies aimed at reprogramming TAMs from the immunosuppressive M2 phenotype to the pro-inflammatory M1 phenotype hold promise for enhancing ICB efficacy. Lipopolysaccharide (LPS), a potent Toll-like receptor 4 (TLR4) ligand, can reprogram TAMs toward an M1 phenotype.
View Article and Find Full Text PDFBiomaterials
January 2025
Department of Nuclear Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, China; Key Laboratory of Biological Nanotechnology, NHC, No. 87 Xiangya Road, Changsha, Hunan, 410008, China. Electronic address:
Osteoarthritis (OA) is a prevalent and debilitating condition characterized by cartilage destruction and inflammation. Traditional pharmacotherapies for OA are limited by their short-term efficacy and systemic side effects. Radiosynoviorthesis (RSO), involving intra-articular injection of radiopharmaceuticals, has shown promise for OA treatment but is hindered by the toxicity and rapid clearance of radioisotopes.
View Article and Find Full Text PDFACS Biomater Sci Eng
January 2025
Chongqing Key Laboratory of Reproductive Health and Digital Medicine, Department of Laboratory Medicine, Chongqing General Hospital, School of Medicine, Chongqing University, Chongqing 401147, China.
Diabetes exacerbates periodontitis by overexpressing reactive oxygen species (ROS), which leads to periodontal bone resorption. Consequently, it is imperative to relieve inflammation and promote alveolar bone regeneration comprehensively for the development of diabetic periodontal treatment strategies. Furthermore, an orderly treatment to avoid interference between these two processes can achieve the optimal therapeutic effect.
View Article and Find Full Text PDFPharmaceutics
December 2024
Department of Pharmacy, Xuzhou Hospital of Traditional Chinese Medicine, Xuzhou 221003, China.
To design a multifunctional nanozyme hydrogel with antibacterial, photo-responsive nitric oxide-releasing, and antioxidative properties for promoting the healing of infected wounds. We first developed ultra-small silver nanoparticles (NPs)-decorated sodium nitroprusside-doped Prussian blue (SNPB) NPs, referred to as SNPB@Ag NPs, which served as a multifunctional nanozyme. Subsequently, this nanozyme, together with geniposide (GE), was incorporated into a thermo-sensitive hydrogel, formulated from Poloxamer 407 and carboxymethyl chitosan, creating a novel antibacterial wound dressing designated as GE/SNPB@Ag hydrogel.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
School of Chemistry and Chemical Engineering, Xi'an University of Architecture and Technology, Xi'an, Shaanxi 710055, China. Electronic address:
In this work, temperature-responsive poly(N-isopropylacrylamide) (PNIPAM) and the guanylthiourea (GLA) were used to modify chitosan (CS) to prepare a novel PNIPAM/GLA/CS adsorbent for Ag(I) ions. Temperature variations near the lower critical solution temperature (LCST) facilitate the adjustment of functional group distribution within the composite material, thereby influencing its adsorption performance for silver ions. The characteristics of this composite material were confirmed using a variety of techniques, including scanning electron microscopy (SEM), variable-temperature ultraviolet-visible near-infrared spectroscopy, Fourier-transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS).
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