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Population Studies and Molecular Mechanisms of Human Radioadaptive Capabilities: Is It Time to Rethink Radiation Safety Standards?
Int J Mol Sci
December 2024
Department of Regenerative Medicine, National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 249036 Obninsk, Russia.
The evolution of man on Earth took place under conditions of constant exposure to background ionizing radiation (IR). From this point of view, it would be reasonable to hypothesize the existence of adaptive mechanisms that enable the human organism to safely interact with IR at levels approximating long-term natural background levels. In some situations, the successful operation of molecular mechanisms of protection against IR is observed at values significantly exceeding the natural background level, for example, in cancer cells.
View Article and Find Full Text PDFRethinking the pan scan in stable trauma: A comparison of whole-body computed tomography and selective imaging in clinically stable blunt force trauma.
Emerg Med Australas
February 2025
Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
Objective: To compare the frequency of clinically significant missed injuries in clinically stable trauma patients undergoing initial whole-body computed tomography (WBCT) versus selective imaging. Secondary objectives include comparisons of radiation exposure, incidental findings, ED length of stay (LOS), hospital LOS and mortality.
Methods: We performed a retrospective cohort study of trauma activations at a tertiary trauma centre in patients with normal vital signs from 1st January 2022 to 31st December 2022.
Guidance for Canadian Breast Cancer Practice: National Consensus Recommendations for Clinical Staging of Patients Newly Diagnosed with Breast Cancer.
Curr Oncol
November 2024
Arthur Child Comprehensive Cancer Centre, Calgary, AB T2N 5G2, Canada.
The accurate staging of breast cancer is fundamental for guiding treatment decisions and predicting patient outcomes. However, there can be considerable variation in routine clinical practice based on individual interpretation of guidelines and depending on the healthcare provider initially involved in working up patients newly diagnosed with breast cancer, ranging from primary care providers, triage nurses, surgeons, and/or oncologists. The optimal approach for clinical staging, particularly in asymptomatic patients presenting with intermediate-risk disease, remains a topic of dialogue among clinicians.
View Article and Find Full Text PDFBreast Cancer Adjuvant Radiotherapy and Chemotherapy Sequencing: Sequential, Concomitant, or What Else? A Comprehensive Review of the Adjuvant Combinations Journey.
J Clin Med
October 2024
Radiation Oncology Unit, Oncology Research Institute of Basilicata-IRCCS-CROB, 85028 Rionero in Vulture, PZ, Italy.
Article Synopsis
- The treatment sequence for breast cancer has traditionally involved adjuvant chemotherapy followed by adjuvant radiotherapy, but advancements in research have prompted questions about optimizing this order.
- Recent studies have explored various sequencing strategies like sequential, concomitant, and sandwich approaches, evaluating their effectiveness and safety for over 8,000 patients across multiple research studies.
- Despite the extensive analysis, a definitive best practice for the sequencing of adjuvant chemotherapy and radiotherapy remains undetermined, highlighting the need for further investigation in this area.
[Events and errors in radiation oncology: Conciliating perspectives to support care].
Cancer Radiother
November 2024
UMR_S 938, service d'oncologie radiothérapie, hôpital Tenon, centre de recherche Saint-Antoine, institut universitaire de cancérologie, Sorbonne université, AP-HP, Paris, France.
The term "event" covers a wide range of concrete situations in radiation oncology, from particularly intense radiation-related side effects to the possibility of technical or human error. Although quality procedures are an integral part of radiotherapy oncology department operations ensuring the analysis and prevention of such events, their occurrence during radiation treatment still has a significant impact on patients and their experience of the treatment process, as well as on health professionals. These practical, emotional and symbolic impacts are all the greater when the event occurs in the aftermath of an error.
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