AI Article Synopsis
- - The stem cell field has rapidly advanced, showing promise for new disease treatments, with stem cells isolated from various adult tissues like bone marrow and fat.
- - Adult tissue stem cells reside in specific microenvironments called niches, crucial for maintaining the health and function of organs throughout life.
- - Certain diseases can harm stem cell populations by disrupting their niches, potentially leading to cell death or even contributing to cancer development, which this review explores in relation to stem cell therapies.
Article Abstract
The stem cell field has grown very rapidly during the last decade, offering the promise of innovative therapies to treat disease. Different stem cell populations have been isolated from various human adult tissues, mainly from bone marrow and adipose tissue, but many other body tissues harbor a stem cell population. Adult tissue stem cells are invariably found in discrete microenvironments termed niches, where they play key roles in tissue homeostasis by enabling lifelong optimization of organ form and function. Some diseases are known to strike at the stem cell population, through alterations in their specific microenvironments, making them non-viable. Furthermore, it has been shown that a transformed stem cell population could prompt the development of certain cancers. This review focuses on the potential negative aspects of a range of diseases on the activity of stem cells and how their potential use in cell therapies may be affected.
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| http://dx.doi.org/10.1159/000489440 | DOI Listing |
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