Nematicidal amide alkaloids from the seeds of Clausena lansium.

Fitoterapia

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China. Electronic address:

Published: July 2018

Five new amide alkaloids (1-3, 5-6) were isolated from the seeds of Clausena lansium together with one new natural product (4) and four known analogues (7-10). The structures of the new amide alkaloids were elucidated based on a comprehensive spectroscopic data analysis including 1D and 2D NMR as well as HRESIMS, and by comparison with the literature. The bioactivity results showed that compound 8 expressed potent nematicidal activity against Panagrellus redivevus, with IC value of 0.12 mM, while compounds 3 and 5 presented moderate nematicidal activity with IC values of 2.75 and 3.93 mM, respectively (abamectin as the positive control with IC value of 1.05 mM).

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http://dx.doi.org/10.1016/j.fitote.2018.04.023DOI Listing

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