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Neuroplasticity and neuroimmune interactions in fatal asthma.
Allergy
November 2024
Departamento de Patologia, LIM-05, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Background: Alteration of airway neuronal function and density and bidirectional interaction between immune cells and sensory peripheral nerves have been proposed to trigger and perpetuate inflammation that contribute to asthma severity. To date, few studies analysed neuroplasticity and neuroinflammation in tissue of asthmatic individuals. We hypothesized that the presence of these phenomena would be a pathological feature in fatal asthma.
View Article and Find Full Text PDFMMGCN: Multi-modal multi-view graph convolutional networks for cancer prognosis prediction.
Comput Methods Programs Biomed
December 2024
School of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, PR China; Big Data Research Center, University of Electronic Science and Technology of China, Chengdu, 611731, PR China. Electronic address:
Background And Objective: Accurate prognosis prediction for cancer patients plays a significant role in the formulation of treatment strategies, considerably impacting personalized medicine. Recent advancements in this field indicate that integrating information from various modalities, such as genetic and clinical data, and developing multi-modal deep learning models can enhance prediction accuracy. However, most existing multi-modal deep learning methods either overlook patient similarities that benefit prognosis prediction or fail to effectively capture diverse information due to measuring patient similarities from a single perspective.
View Article and Find Full Text PDFArrhythmogenic cardiomyopathy-related cadherin variants affect desmosomal binding kinetics.
J Mol Cell Cardiol
October 2024
Department of Physics, Experimental Biophysics and Applied Nanoscience, Bielefeld University, Universitätsstraße 25, Bielefeld, Germany.
Article Synopsis
- Mutations in the genes for Dsg2 and Dsc2 are linked to arrhythmogenic right ventricular cardiomyopathy (ARVC), a serious heart condition, and the study investigates how different variants of these proteins behave.
- Through advanced techniques, the research reveals that while mutations don’t change the binding structure of these proteins, they affect how quickly they attach and detach from each other, potentially contributing to the development of ARVC by altering cell adhesion dynamics.
Desmosomal Hyper-Adhesion Affects Direct Inhibition of Desmoglein Interactions in Pemphigus.
J Invest Dermatol
December 2024
Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig Maximilian University of Munich, Munich, Germany. Electronic address:
During differentiation, keratinocytes acquire a strong, hyper-adhesive state, where desmosomal cadherins interact calcium ion independently. Previous data indicate that hyper-adhesion protects keratinocytes from pemphigus vulgaris autoantibody-induced loss of intercellular adhesion, although the underlying mechanism remains to be elucidated. Thus, in this study, we investigated the effect of hyper-adhesion on pemphigus vulgaris autoantibody-induced direct inhibition of desmoglein (DSG) 3 interactions by atomic force microscopy.
View Article and Find Full Text PDFSelf-recognition is a fundamental cellular process across evolution and forms the basis of neuronal self-avoidance1-4. Clustered protocadherins (Pcdh), comprising a large family of isoform-specific homophilic recognition molecules, play a pivotal role in neuronal self-avoidance required for mammalian brain development5-7. The probabilistic expression of different Pcdh isoforms confers unique identities upon neurons and forms the basis for neuronal processes to discriminate between self and non-self5,6,8.
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