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Microneedle transdermal delivery of compound betamethasone in alopecia areata-A randomized controlled trial.
J Am Acad Dermatol
October 2024
Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China. Electronic address:
Article Synopsis
- Alopecia areata (AA) causes significant discomfort for patients, and the study aimed to evaluate the effectiveness and pain levels of a new treatment method using microneedles for delivering betamethasone compared to traditional injections.
- The randomized trial included 80 patients with mild-to-moderate AA, showing similar reductions in hair loss (measured by SALT score) between both treatment groups after three months, but with notably less pain reported in the microneedle group.
- While both treatments were effective, the study's limitations include a focus solely on mild-to-moderate cases, leaving out information on how these methods work for more severe forms of AA.
Calcipotriene/Betamethasone Dipropionate Foam as a Potential Safe and Effective Treatment of Nail Psoriasis.
Skin Appendage Disord
February 2024
Department of Dermatology, University of Alabama at Birmingham Medical Center, Birmingham, AL, USA.
Background: Nail psoriasis is a common condition that affects quality of life in individuals with psoriasis and psoriatic arthritis. Topical treatments have been shown to be effective in treating nail bed disease but not as effective in treating nail matrix diseases, which often requires intralesional corticosteroids.
Objectives: The objective of this open-label study was to evaluate the efficacy of combination calcipotriol/betamethasone dipropionate foam as a treatment for nail psoriasis including nail matrix disease.
Treatments for alopecia areata: a network meta-analysis.
Cochrane Database Syst Rev
October 2023
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Background: Alopecia areata is an autoimmune disease leading to nonscarring hair loss on the scalp or body. There are different treatments including immunosuppressants, hair growth stimulants, and contact immunotherapy.
Objectives: To assess the benefits and harms of the treatments for alopecia areata (AA), alopecia totalis (AT), and alopecia universalis (AU) in children and adults.
Intralesional betamethasone versus oral propranolol for localized infantile hemangiomas of the lip.
J Plast Reconstr Aesthet Surg
December 2023
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Infantile hemangiomas (IHs) of the lips are associated with an increased risk of incomplete involution and ulceration, causing disfigurement. Treatment with oral propranolol (OPT) has credible efficacy but takes months to complete. Thus, this study aimed to investigate the efficacy of intralesional betamethasone injection (IBI) as an alternative treatment for protruding localized IHs of the lips.
View Article and Find Full Text PDFLayered GelMA/PEGDA Hydrogel Microneedle Patch as an Intradermal Delivery System for Hypertrophic Scar Treatment.
ACS Appl Mater Interfaces
September 2023
Department of Plastic Surgery, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Hypertrophic scar (HS) is an unfavorable skin disorder that typically develops after trauma, burn injury, or surgical procedures and causes numerous physical and psychological issues in patients. Currently, intralesional multi-injection of corticosteroid, particularly compound betamethasone (CB), is one of the most prevalent treatments for HS. However, injection administration could result in severe pain and dose-related side effects.
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