AI Article Synopsis
- A new copper-catalyzed reaction has been created for efficiently synthesizing substituted pyrroles from enamino esters through a combined oxidative cyclization and amino migration process.
- The reaction involves breaking one C-N bond while forming two new C-N bonds and one C(sp)-C(sp) bond in a single step, showcasing its efficiency.
- It operates under mild conditions, uses oxygen as the oxidant, and works well with various functional groups, producing valuable aminomethyl-substituted pyrroles with good yields.
Article Abstract
A novel and efficient copper-catalyzed tandem oxidative cyclization/1,2-amino migration of readily available enamino esters for the synthesis of substituted pyrroles has been developed. In this reaction, one C-N bond was cleaved, and two new C-N bonds and one C(sp)-C(sp) bond were constructed in one pot. This catalytic system has the obvious advantages of mild reaction conditions and the use of oxygen as the oxidant. The reaction tolerates a wide range of functional groups and is a reliable method for the straightforward synthesis of valuable aminomethyl-substituted pyrroles in good yields.
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| http://dx.doi.org/10.1021/acs.orglett.8b01139 | DOI Listing |
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