Summary: We present DETECT v2-an enzyme annotation tool which considers the effect of sequence diversity when assigning enzymatic function [as an Enzyme Commission (EC) number] to a protein sequence. In addition to capturing more enzyme classes than the previous version, we now provide EC-specific cutoffs that greatly increase precision and recall of assignments and show its performance in the context of pathways.
Availability And Implementation: https://github.com/ParkinsonLab/DETECT-v2.
Supplementary Information: Supplementary data are available at Bioinformatics online.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157075 | PMC |
http://dx.doi.org/10.1093/bioinformatics/bty368 | DOI Listing |
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