Improved enzyme annotation with EC-specific cutoffs using DETECT v2.

Bioinformatics

Program in Molecular Medicine, The Hospital for Sick Children, 21-9709 PGCRL, 686 Bay Street, Toronto, ON, Canada.

Published: October 2018

Summary: We present DETECT v2-an enzyme annotation tool which considers the effect of sequence diversity when assigning enzymatic function [as an Enzyme Commission (EC) number] to a protein sequence. In addition to capturing more enzyme classes than the previous version, we now provide EC-specific cutoffs that greatly increase precision and recall of assignments and show its performance in the context of pathways.

Availability And Implementation: https://github.com/ParkinsonLab/DETECT-v2.

Supplementary Information: Supplementary data are available at Bioinformatics online.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157075PMC
http://dx.doi.org/10.1093/bioinformatics/bty368DOI Listing

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