Introduction: The estimation of the non-linear viscoelastic characteristics of human soft tissues, such as ligaments and tendon, is often affected by the implemented procedure. This study aims at developing and validating a protocol, associated with a contactless and automatic procedure, enabling the determination of the material behavior and properties of any soft tissues.
Methods: Several markers were drawn onto the soft tissue specimen analyzed under uniaxial tensile test. An automatic contactless procedure, that uses a camera for recording the position of the markers during the test, was developed to compute the displacement, and the force applied, enabling the calculation of the true-stress/strain curve of the material. Young's modulus and Poisson's ratio can be calculated, on demand, for selected regions of interest of the soft tissues. The repeatability and reproducibility of the procedure were analyzed. The procedure was initially tested and verified on an artificial silicone material and later applied for investigating the mechanical behavior of a pig Achilles tendon and of a human patellar tendon.
Results: The procedure show a high repeatability, independent by the operator, reliability and accuracy for the tested synthetic material (with a maximum error of 3.7% for Young's modulus). Additionally, the developed protocol was also suitable for the analysis of animal and human soft tissues.
Conclusion: A protocol to automatically and accurately determine material properties in soft tissues was developed, tested and validated. Such approach could successfully be implemented for the mechanical characterization of any biological soft-tissue.
Level Of Evidence: V.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908329 | PMC |
| http://dx.doi.org/10.11138/mltj/2017.7.4.529 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Corrigendum to "Soft tissue flap reconstruction in infected or exposed total knee arthroplasty: A systematic review and network meta-analysis" [The Knee 52 (2025) 9-21].
Knee
January 2025
Department of Plastic Surgery, University of Pittsburgh Medical Center, 3550 Terrace Street 6B Scaife Hall, Pittsburgh, PA 15261, USA.
Suppression of METTL3 expression attenuated matrix stiffness-induced vaginal fibroblast-to-myofibroblast differentiation and abnormal modulation of the extracellular matrix in pelvic organ prolapse.
Chin Med J (Engl)
January 2025
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing 100730, China.
Background: Fibrosis of the connective tissue in the vaginal wall predominates in pelvic organ prolapse (POP), which is characterized by excessive fibroblast-to-myofibroblast differentiation and abnormal deposition of the extracellular matrix (ECM). Our study aimed to investigate the effect of ECM stiffness on vaginal fibroblasts and to explore the role of methyltransferase 3 (METTL3) in the development of POP.
Methods: Polyacrylamide hydrogels were applied to create an ECM microenvironment with variable stiffness to evaluate the effects of ECM stiffness on the proliferation, differentiation, and expression of ECM components in vaginal fibroblasts.
Temporary ectopic banking as a treatment option for mangled thumb: a case report.
J Med Case Rep
January 2025
Bone and Joint Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Management of the extensive soft tissue injuries remains a significant challenge in orthopedic and plastic reconstructive surgery. Since the thumb is responsible for 40% of the functions of the hand, saving and reconstructing a mangled thumb is essential for the patient's future.
Case Presentation: This case report describes the management of a severe occupational thumb injury in a 25-year-old white Persian male who sustained an occupational injury to his left thumb, resulting in extensive burn, crush injury to the distal and proximal phalanx, and severe soft tissue damage to the first metacarpal, thenar, and palmar areas.
Whole-transcriptome analysis reveals the profiles and roles of coding and non-coding RNAs during hair follicle cycling in Rex rabbits.
BMC Genomics
January 2025
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Background: Rex rabbit is famous for its silky and soft fur coat, a characteristic predominantly attributed to its hair follicles. Numerous studies have confirmed the crucial roles of mRNAs and non-coding RNAs (ncRNAs) in regulating key cellular processes such as cell proliferation, differentiation, apoptosis and immunity. However, their involvement in the regulation of the hair cycle in Rex rabbits remains unknown.
View Article and Find Full Text PDFA multicenter study of neurofibromatosis type 1 utilizing deep learning for whole body tumor identification.
NPJ Digit Med
January 2025
Neurofibromatosis Type 1 Center and Laboratory for Neurofibromatosis Type 1 Research, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Deep-learning models have shown promise in differentiating between benign and malignant lesions. Previous studies have primarily focused on specific anatomical regions, overlooking tumors occurring throughout the body with highly heterogeneous whole-body backgrounds. Using neurofibromatosis type 1 (NF1) as an example, this study developed highly accurate MRI-based deep-learning models for the early automated screening of malignant peripheral nerve sheath tumors (MPNSTs) against complex whole-body background.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!