AI Article Synopsis
- PEDF is a secreted glycoprotein with various biological functions, including neuroprotection and anti-cancer effects, particularly in cancers like prostate, ovarian, and pancreatic.
- The study investigated the role of PEDF in colorectal cancer by measuring its expression in human cancer tissues and evaluating the effects of recombinant PEDF on cancer cell behavior.
- Findings showed that PEDF levels were lower in colorectal cancer tissues, and treatment with recombinant PEDF reduced cancer cell migration and invasion while enhancing cell adhesion, suggesting that increasing PEDF levels could be a potential therapeutic strategy to prevent colorectal cancer metastasis.
Article Abstract
Pigment epithelial derived factor (PEDF) is a secreted glycoprotein that is a non-inhibitory member of the serine protease inhibitor (serpin) family. PEDF exhibits multiple biological properties including neuroprotective, anti-angiogenic, and immune-modulating. Interestingly, PEDF exerts the inhibitory effects in cancers derived from certain tissues, including prostatic, ovarian, and pancreatic carcinomas. The current study aimed to elucidate its role in colorectal cancer development. PEDF expression in human colorectal cancer tissue was assessed using quantitative polymerase chain reaction (qPCR) and immunohistochemical staining (IHC). The effect of treatment with recombinant PEDF on cellular function was examined using functional assays. PEDF expression was downregulated in colorectal cancer cell tissue. Treatment with recombinant PEDF resulted in significant decreases in the rate of colorectal cancer cell migration and invasion and an increase in cellular adhesion in colorectal cancer cell lines examined. These results indicate that upregulation of PEDF expression may serve as a new strategy for further investigation of therapeutic relevance to the prevention of the metastatic spread of colorectal cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922387 | PMC |
| http://dx.doi.org/10.18632/oncotarget.24953 | DOI Listing |
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