AI Article Synopsis
- Mitral regurgitation (MR) happens when the components of the mitral valve and ventricle are disrupted, leading to changes in the left ventricle (LV) shape and potential heart failure.
- If left untreated, an increased left ventricular end-systolic volume index (over 55 ml/m2) can result in serious complications like heart failure and dangerous arrhythmias.
- The study aims to outline the process of LV remodeling in MR and highlight new treatments that not only fix the valve but also reshape the ventricle for better heart function.
Article Abstract
Mitral regurgitation (MR) occurs when any of the valve and ventricular mitral apparatus components are disturbed. As MR progresses, left ventricular remodelling occurs, ultimately causing heart failure when the enlarging left ventricle (LV) loses its conical shape and becomes globular. Heart failure and lethal ventricular arrhythmias may develop if the left ventricular end-systolic volume index exceeds 55 ml/m2. These adverse changes persist despite satisfactory correction of the annular component of MR. Our goal was to describe this process and summarize evolving interventions that reduce the volume of the left ventricle and rebuild its elliptical shape. This 'valve/ventricle' approach addresses the spherical ventricular culprit and offsets the limits of treating MR by correcting only its annular component.
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| http://dx.doi.org/10.1093/ejcts/ezy174 | DOI Listing |
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