Several immune markers have been studied in controlling American tegumentary leishmaniosis based on mouse models. However, there is a lack of studies regarding human tegumentary leishmaniosis caused by Leishmania braziliensis. In this study, hypoxia-inducible factor-1α was found to be an important effector element in the localized control of human cutaneous and mucocutaneous lesions.
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Evaluation of the public health laboratory network for tegumentary leishmaniasis in an endemic area of Brazil.
Rev Inst Med Trop Sao Paulo
December 2024
Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Pesquisa Clínica e Vigilância em Leishmaniose, Rio de Janeiro, Rio de Janeiro, Brazil.
Diagnostic networks ensure efficiency in disease diagnosis. A descriptive study evaluated the network of public health laboratories (NPHL) in Minas Gerais State, Brazil, using diagnostic results for tegumentary leishmaniasis (TL) from the laboratory management system in 2017-2020. Out of 1,369 individuals analyzed, 704 (51.
View Article and Find Full Text PDFUrine and serum-based ELISA using a recombinant protein and synthetic peptide for the diagnosis of tegumentary leishmaniasis.
Diagn Microbiol Infect Dis
November 2024
Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil; Departamento de Patologia Clínica, COLTEC, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Brazil. Electronic address:
The diagnosis of tegumentary leishmaniasis (TL) presents problems by the variable sensitivity and specificity of the tests, and the biological samples used are also invasive. Here, ELISA experiments were performed using paired TL patient urine and serum samples in reaction against the recombinant LiHyS protein, a predicted B cell epitope and parasite antigenic extract (SLA). Two hundred and five paired samples were used, which were provided by TL patients, healthy controls and patients with Chagas disease, leprosy, malaria or HIV-infected.
View Article and Find Full Text PDFUnderstanding American tegumentary leishmaniasis in urban Montes Claros, Brazil: insights from clinical, immunological and therapeutic investigations.
Parasitology
November 2024
Center for Molecular and Cellular Biosciences, School of Biological, Environmental, and Earth Sciences, University of Southern Mississippi, Hattiesburg, MS, USA.
The challenge of American tegumentary leishmaniasis (ATL) continues in Brazil, presenting a persistent public health issue despite initiatives aimed at public outreach, vector control and health education. To gain a deeper understanding of this disease, a study was conducted in an endemic region located in the northern region of the state of Minas Gerais, Brazil. The study monitored 30 resident patients diagnosed with ATL, using serum samples from 6 healthy individuals as controls.
View Article and Find Full Text PDFTreatment of Refractory Mucosal Leishmaniasis Is Associated with Parasite Overexpression of HSP70 and ATPase and Reduced Host Hydrogen Peroxide Production (Brief Report).
Biomedicines
September 2024
Post-Graduation Program in Clinical Medicine (PPGCM), Faculty of Medicine (FM), Campus Universitário Darcy Ribeiro, University of Brasília (UnB), UnB Área 1-Asa Norte, Brasilia 70910-900, DF, Brazil.
Background: Mucosal leishmaniasis (ML) is a deforming type of American Tegumentary Leishmaniasis caused by () that frequently does not respond to treatment. Despite its relapsing clinical course, few parasites are usually found in mucosal lesions. Host and parasite factors may be responsible for this paradox in the pathogenesis of the disease, allowing for both a low parasite burden and the inability of the host to clear and eliminate the disease.
View Article and Find Full Text PDFDiagnostic performance of Leishmania braziliensis and Leishmania peruviana antigens in the immunoblot method for the detection of american tegumentary leishmaniasis.
Rev Peru Med Exp Salud Publica
October 2024
Centro Nacional de Salud Pública, Instituto Nacional de Salud, Lima, Perú.
Article Synopsis
- The study investigates the immunogenic properties of soluble and excretion/secretion antigens from Leishmania braziliensis and Leishmania peruviana to identify potential diagnostic proteins for American Tegumentary Leishmaniasis (ATL).
- Key findings reveal that the soluble antigen of Leishmania braziliensis has high sensitivity (87.7%) and perfect specificity (100%) for ATL detection, while Leishmania peruviana shows slightly better sensitivity (92.3%) and good specificity (95.7%).
- The research suggests that using immunoblot techniques can enhance the diagnostic accuracy for ATL, particularly in challenging cases, and emphasizes the need to further characterize the identified immunogenic regions for developing effective recombinant and synthetic proteins
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