We present an experimental demonstration of a subwavelength diffraction grating performing first-order differentiation of the transverse profile of an incident optical beam with respect to a spatial variable. The experimental results are in a good agreement with the presented analytical model suggesting that the differentiation is performed in transmission at oblique incidence and is associated with the guided-mode resonance of the grating. According to this model, the transfer function of the grating in the vicinity of the resonance is close to the transfer function of an exact differentiator. We confirm this by estimating the transfer function of the fabricated structure on the basis of the measured profiles of the incident and transmitted beams. The considered structure may find application in the design of new photonic devices for beam shaping, optical information processing, and analog optical computing.
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http://dx.doi.org/10.1364/OE.26.010997 | DOI Listing |
J Neuroimmune Pharmacol
January 2025
Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, PR China.
Emerging evidence highlights the significance of peripheral inflammation in the pathogenesis of Parkinson's disease (PD) and suggests the gut as a viable therapeutic target. This study aimed to explore the neuroprotective effects of the probiotic formulation VSL#3 and its underlying mechanism in a PD mouse model induced by MPTP. Following MPTP administration, the striatal levels of dopamine and its metabolites, as along with the survival rate of dopaminergic neurons in the substantia nigra, were significantly reduced in PD mice.
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Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Fluorescent biosensors offer a powerful tool for tracking and quantifying protein activity in living systems with high temporospatial resolution. However, the expression of genetically encoded fluorescent proteins can interfere with endogenous signaling pathways, potentially leading to developmental and physiological abnormalities. The EKAREV-NLS mouse model, which carries a FRET-based biosensor for monitoring extracellular signal-regulated kinase (ERK) activity, has been widely utilized both in vivo and in vitro across various cell types and organs.
View Article and Find Full Text PDFMikrochim Acta
January 2025
College of Geography and Environmental Sciences, College of Chemistry and Materials Science, Zhejiang Normal University, Jinhua, 321004, China.
Myoglobin (Mb), an important cardiac marker, plays a crucial role in diagnosing, monitoring, and evaluating the condition of patients with cardiovascular diseases. Here, we propose a label-free photoelectrochemical (PEC) sensor for the detection of Mb through target regulated the photoactivity of AgS/FeOOH heterojunction. The AgS/FeOOH nanospindles were synthesized and served as a sensing platform for the fabrication of bio-recognized process for Mb.
View Article and Find Full Text PDFPsychol Res
January 2025
Department of Psychology, Izmir University of Economics, Izmir, Turkey.
The Spatial-Numerical Association of Response Codes (SNARC) effect refers to the phenomenon of faster left-hand responses to smaller numbers and faster right-hand responses to larger ones. The current study examined the possible long-lasting effects of magnitude-relevant stimulus-response compatibility (SRC) practices on the SNARC effect in a transfer paradigm. Participants performed a magnitude classification task including either SNARC-compatible or SNARC-incompatible trials as practice.
View Article and Find Full Text PDFJ Phys Chem A
January 2025
School of Applied Science and Humanities, Haldia Institute of Technology, ICARE Complex, Haldia 721657, India.
This study explores the reactivity of a new intermolecular P/B frustrated Lewis pair in the context of dinitrogen activation through a push-pull mechanism. The ab initio molecular dynamics model known as atom-centered density matrix propagation plays a pivotal role in elucidating the weakly associated encounter complex. In-depth analysis, mainly through intrinsic reaction coordinate calculations, supports a single-step mechanism.
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