High-order harmonic generation from relativistic laser-driven plasma mirrors is an attractive route to produce highly energetic attosecond pulses in the extreme ultraviolet to x-ray regime. To achieve an isolated attosecond pulse (IAP) driven by many-cycle intense laser pulses, pulse engineering techniques such as polarization modulation and wavefront rotation, are usually needed. Here we show that it is possible to generate an IAP without pulse engineering. Through particle-in-cell simulations, it is found that plasma mirrors can be rapidly heated and deformed in a relatively long preplasma regime. Intense IAP in the high-frequency spectral region is given rise once when the mirror parameters are suitable. The results may offer a new route to generate a bright IAP source for various applications such as bio-imaging and electronic dynamic studies.
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http://dx.doi.org/10.1364/OL.43.002114 | DOI Listing |
PLoS One
January 2025
Center for Innovation in Brain Science, University of Arizona Health Sciences, Tucson, Arizona, United States of America.
Translational validity of mouse models of Alzheimer's disease (AD) is variable. Because change in weight is a well-documented precursor of AD, we investigated whether diversity of human AD risk weight phenotypes was evident in a longitudinally characterized cohort of 1,196 female and male humanized APOE (hAPOE) mice, monitored up to 28 months of age which is equivalent to 81 human years. Autoregressive Hidden Markov Model (AHMM) incorporating age, sex, and APOE genotype was employed to identify emergent weight trajectories and phenotypes.
View Article and Find Full Text PDFFluids Barriers CNS
January 2025
Neurology 5 - Neuropathology Unit, Fondazione IRCCS - Istituto Neurologico Carlo Besta, Via Celoria 11, Milan, 20133, Italy.
Background: The approval of new disease-modifying therapies by the U.S. Food and Drug Administration and the European Medicine Agency makes it necessary to optimize non-invasive and cost-effective tools for the identification of subjects at-risk of developing Alzheimer's Disease (AD).
View Article and Find Full Text PDFRheumatology (Oxford)
January 2025
Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden.
Objectives: To investigate the occurrence and dynamics of secretory component-containing antibodies towards citrullinated proteins (SC ACPA) in plasma from pre-symptomatic individuals subsequently developing rheumatoid arthritis (RA).
Methods: We studied 319 individuals who had donated plasma prior to RA onset (median predating time 4.7 years), whereof 181 also donated samples after diagnosis.
Dent Mater
January 2025
Department of Restorative Dentistry, University of Manitoba, Winnipeg, MB, R3E 0W2, Canada.
Objective: This study aimed to evaluate the chemical solubility (CS) and conduct a comprehensive physicochemical characterization of several experimental and commercial lithium silicate-based glass-ceramics towards an understanding of the chemical processes governing dissolution in these glass-ceramics.
Methodology: Glass-ceramic (GC) samples were categorized into two groups: experimental materials featuring lithium metasilicate crystals (GCE1 and GCE2); and five commercial brands relying mostly on lithium disilicate (Celtra®Duo, IPS e.max®CAD, Straumann®n!ce®, CEREC Tessera™, and VITA Suprinity®).
FEBS J
January 2025
Physics, Department of Molecular and Translational Medicine, University of Brescia, Italy.
Neutrophil elastase (NE) is released by activated neutrophils during an inflammatory response and exerts proteolytic activity on elastin and other extracellular matrix components. This protease is rapidly inhibited by the plasma serine protease inhibitor alpha-1-antitrypsin (AAT), and the importance of this protective activity on lung tissue is highlighted by the development of early onset emphysema in individuals with AAT deficiency. As a serpin, AAT presents a surface-exposed reactive centre loop (RCL) whose sequence mirrors the target protease specificity.
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