AI Article Synopsis

  • Diabetes is a global epidemic causing serious health issues, leading to significant complications that increase morbidity and mortality rates.
  • Research shows that oxidative stress and inflammation play key roles in the development of these complications in diabetic patients.
  • The review aims to explore the specific mechanisms behind these complications and examines new therapies targeting oxidative stress and inflammation to improve outcomes for diabetes sufferers.

Article Abstract

Diabetes is considered a major burden on the healthcare system of Western and non-Western societies with the disease reaching epidemic proportions globally. Diabetic patients are highly susceptible to developing micro- and macrovascular complications, which contribute significantly to morbidity and mortality rates. Over the past decade, a plethora of research has demonstrated that oxidative stress and inflammation are intricately linked and significant drivers of these diabetic complications. Thus, the focus now has been towards specific mechanism-based strategies that can target both oxidative stress and inflammatory pathways to improve the outcome of disease burden. This review will focus on the mechanisms that drive these diabetic complications and the feasibility of emerging new therapies to combat oxidative stress and inflammation in the diabetic milieu.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905388PMC
http://dx.doi.org/10.1002/cti2.1016DOI Listing

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