Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/fon-2018-0025 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: Neuroinflammation is an integral part of Alzheimer's Disease (AD) pathology, whereby inflammatory processes contribute to the production of amyloid-β, the propagation of tau pathology, and neuronal loss. We recently investigated data-driven methods for determining distinct progression trajectory groups on the ADCOMS scale. This study evaluates whether biomarkers of inflammation in cerebrospinal fluid (CSF) can predict progression rate and membership of those progression rate groups.
View Article and Find Full Text PDF[Diagnosis and clinicopathological analysis of pituitary neuroendocrine tumors based on the 5th WHO classification].
Zhonghua Bing Li Xue Za Zhi
January 2025
Department of Pathology, the First Affiliated Hospital of University of Science and Technology of China/Anhui Provincial Hospital, Hefei230036, China.
Appendiceal Neuroendocrine Tumor: Clinicopathologic Characteristics of Six Cases and Review of the Literature.
In Vivo
December 2024
Department of Pathology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea;
Background/aim: Appendiceal neuroendocrine tumors (ANETs) are the most prevalent type of appendiceal neoplasm and the fifth most common neuroendocrine tumor in the gastrointestinal tract. In this study, we described the clinicopathological features of patients with ANET.
Patients And Methods: We reviewed the clinicopathological findings and histopathological reports of six patients diagnosed with ANET between January 2014 and December 2023 at Korea University Medical Center, Anam Hospital.
Characterization of Epithelial-Mesenchymal and Neuroendocrine Differentiation States in Pancreatic and Small Cell Ovarian Tumor Cells and Their Modulation by TGF-β1 and BMP-7.
Cells
December 2024
Biochemistry and Tumor Biology Lab, Department of Obstetrics and Gynecology, Hannover Medical School, 30625 Hannover, Germany.
Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis, due in part to early invasion and metastasis, which in turn involves epithelial-mesenchymal transition (EMT) of the cancer cells. Prompted by the discovery that two PDAC cell lines of the quasi-mesenchymal subtype (PANC-1, MIA PaCa-2) exhibit neuroendocrine differentiation (NED), we asked whether NED is associated with EMT. Using real-time PCR and immunoblotting, we initially verified endogenous expressions of various NED markers, i.
View Article and Find Full Text PDFTherapeutic Exploitation of Neuroendocrine Transdifferentiation Drivers in Prostate Cancer.
Cells
December 2024
Vancouver Prostate Centre, Department of Urological Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.
Neuroendocrine prostate cancer (NEPC), an aggressive and lethal subtype of prostate cancer (PCa), often arises as a resistance mechanism in patients undergoing hormone therapy for prostate adenocarcinoma. NEPC is associated with a significantly poor prognosis and shorter overall survival compared to conventional prostate adenocarcinoma due to its aggressive nature and limited response to standard of care therapies. This transdifferentiation, or lineage reprogramming, to NEPC is characterised by the loss of androgen receptor (AR) and prostate-specific antigen (PSA) expression, and the upregulation of neuroendocrine (NE) biomarkers such as neuron-specific enolase (NSE), chromogranin-A (CHGA), synaptophysin (SYP), and neural cell adhesion molecule 1 (NCAM1/CD56), which are critical for NEPC diagnosis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!