Proliferation of cytotoxic T-cells, a prerequisite for the development of antitumor vaccines, was induced by 1, but not by its partial structures A and B. The conjugate 1 containing a tumor-associated Sialyl-T -MUC-1 glycopeptide antigen A and a T-cell epitope B of tetanus toxin was synthesized by fragment condensation on a solid phase.

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http://dx.doi.org/10.1002/1521-3773(20010119)40:2<366::AID-ANIE366>3.0.CO;2-JDOI Listing

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